MABN863

Anti-Cav1.2 alpha1c, clone 8F9.1 Antibody

clone 8F9.1, from mouse

• Synonyme(s) : Voltage-dependent L-type calcium channel subunit alpha-1C, Calcium channel, L type. alpha-1 polypeptide, isoform 1, cardiac muscle, Voltage-gated calcium channel subunit alpha Cav1.2
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: mouse
• Niveau de qualité: 100
• Forme d'anticorps: purified immunoglobulin
• Type de produit anticorps: primary antibodies
• Clone: 8F9.1, monoclonal
• Espèces réactives: human
• Technique(s): immunohistochemistry: suitable (paraffin); western blot: suitable
• Isotype: IgG1κ
• Numéro d'accès NCBI: NP_000710
• Numéro d'accès UniProt: Q13936
• Conditions d'expédition: wet ice
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... CACNA1C(775)

Description

Description générale

This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Many alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Immunogène

Recombinant protein corresponding to human Cav1.2 alpha1c.

Application

Anti-Cav1.2 alpha1c, clone 8F9.1 | MABN863 is an antibody against Cav1.2 alpha1c for use in Western Blotting, Immunohistochemistry (Paraffin).

Immunohistochemistry Analysis: A 1:250-1,000 dilution from a representative lot detected Cav1.2 alpha1c in human cerebellum, human cerebral cortex, and human pancreas tissue.

Research Category
Neuroscience

Research Sub Category
Developmental Signaling

Qualité

Evaluated by Western Blotting in human brain tissue lysate.

Western Blotting Analysis: 5.0 µg/mL of this antibody detected Cav1.2 alpha1c in 10 µg of human brain tissue lysate.

Description de la cible

~230 kDa observed. UniProt entry Q13936 describes 37 isoforms produced by alternative splicing.

Forme physique

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stockage et stabilité

Stable for 1 year at 2-8°C from date of receipt.

Autres remarques

Concentration: Please refer to lot specific datasheet.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 1