MABN296

Anti-RLBP1 Antibody, clone 3C1.1

clone 3C1.1, from mouse

• Synonyme(s) : Anti-Retinaldehyde-binding protein 1, Cellular retinaldehyde-binding protein, RLBP1
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: mouse
• Niveau de qualité: 100
• Forme d'anticorps: purified immunoglobulin
• Type de produit anticorps: primary antibodies
• Clone: 3C1.1, monoclonal
• Espèces réactives: human, rat
• Technique(s): immunohistochemistry: suitable; western blot: suitable
• Isotype: IgG1κ
• Numéro d'accès NCBI: NP_000317
• Numéro d'accès UniProt: P12271
• Conditions d'expédition: wet ice
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... RLBP1(6017)

Description

Description générale

Retinaldehyde-binding protein 1 (RLBP1), also known as Cellular retinaldehyde-binding protein, and encoded by the gene RLBP1/CRALBP, is a soluble retinoid carrier protein essential for the proper function of both rod and cone photoreceptors. RLBP1 participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the “visual cycle”. RLBP1 is localized to the cytoplasm. RLBP1 is expressed in retina and pineal gland. It not present in photoreceptor cells but is expressed abundantly in the adjacent retinal pigment epithelium (RPE) and in the Mueller glial cells of the retina. Defects in RLBP1 may be associated with Retinitis pigmentosa, Bothnia retinal dystrophy (BRD), Rod-cone dystrophy Newfoundland, and Retinitis punctata albescens genetic diseases.

Immunogène

GST-tagged recombinant protein corresponding to human RLBP1.

Application

Anti-RLBP1 Antibody, clone 3C1.1 is a highly specific mouse monoclonal antibody, that targets Retinaldehyde-binding protein 1 & has been tested in western blotting & IHC.

Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected RLBP1 in human retina and rat retina tissue.

Research Category
Neuroscience

Research Sub Category
Developmental Signaling

Qualité

Evaluated by Western Blotting in rat eye tissue lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected RLBP1 in 10 µg of rat eye tissue lysate.

Description de la cible

~37 kDa observed

Forme physique

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stockage et stabilité

Stable for 1 year at 2-8°C from date of receipt.

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable