MABF150E

Anti-IL-2 (mouse), PE, clone JES6-5H4 Antibody

clone JES6-5H4, from rat, PE

• Synonyme(s) : Interleukin-2 (IL-2), T-cell growth factor (TCGF), IL-2
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rat
• Niveau de qualité: 100
• Conjugué: PE
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: JES6-5H4, monoclonal
• Espèces réactives: mouse
• Conditionnement: antibody small pack of 25 μg
• Technique(s): flow cytometry: suitable
• Isotype: IgG2bκ
• Numéro d'accès UniProt: P04351
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: mouse ... Il2(16183)

Description

Description générale

The JES6-5H4 antibody binds to mouse Interleukin-2 (IL-2), a 17 kDa cytokine that is secreted by activated T cells. This cytokine acts as an autocrine stimulatory factor for T cell proliferation, differentiation and survival, as well as being an effective activator of B cells and inducer of NK cell cytotoxic functions. IL-2 plays a key modulatory role in the differentiation of T cells toward either Th17 or T regulatory (Treg) cell types and is important for Treg cell function. The IL-2 receptor (IL-2R) is a complex consisting of an IL-2R alpha chain (CD25), along with the IL-2R beta chain (CD122) and the common gamma chain (CD132). IL-2 may also bind with low affinity to the T cell surface protein CD25 alone, although this interaction does not induce cell signaling.

Application

This rat monoclonal Anti-IL-2 Antibody (mouse), PE, clone JES6-5H4, Cat. No. MABF1510 is validated for use in Flow Cytometry, for the detection of IL-2.

Qualité

This monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

Flow Cytometry Analysis: 0.06 μg from a representative lot detected IL-2 in one million C57Bl/6 splenocytes.

Autres remarques

Concentration: Please refer to lot specific datasheet.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): nwg