MABE989

Anti-Homeodomain-only Protein Antibody, clone 15C1.1

clone 15C1.1, from mouse

• Synonyme(s) : Lung cancer-associated Y protein, Homeodomain-only Protein, Not expressed in choriocarcinoma protein 1, Odd homeobox protein 1
• Code UNSPSC : 12352203
• eCl@ss : 32160702

Propriétés

• Source biologique: mouse
• Niveau de qualité: 100
• Forme d'anticorps: purified immunoglobulin
• Type de produit anticorps: primary antibodies
• Clone: 15C1.1, monoclonal
• Espèces réactives: mouse
• Réactivité de l'espèce (prédite par homologie): human (based on 100% sequence homology)
• Technique(s): western blot: suitable
• Isotype: IgG2bκ
• Numéro d'accès NCBI: NP_001138931
• Numéro d'accès UniProt: Q9BPY8
• Conditions d'expédition: wet ice
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... HOPX(84525)

Description

Description générale

Homeodomain-only protein (UniProt Q9BPY8; also known as Lung cancer-associated Y protein, Not expressed in choriocarcinoma clone 1, Not expressed in choriocarcinoma protein 1, Odd homeobox 1 protein, Odd homeobox protein 1) is encoded by the HOPX (also known as CAMEO, HOD, HOP, LAGY, NECC1, OB1, SMAP31, TOTO) gene (Gene ID 84525) in human. Human and mouse HOPX proteins share 92% identity, they contain homeobox-like domain but lack sequence motif required for DNA binding. HOPX is highly expressed in the developing heart, where its expression is dependent on the cardiac-restricted homeobox protein, Nkx2.5. HOPX physically interacts with serum responsive factor (SRF) and inhibits SRF-dependent transcription by inhibiting SRF binding to DNA and by recruiting histone deacetylase (HDAC) activity. HOPX is reported to play a critical role in the differentiation of various cells such as myoblasts, trophoblasts, keratinocytes, T cells, and lung alveolar cells. HOPX was initially reported as a differentiation marker and is expressed in various normal tissues, and HOPX expression is markedly suppressed in a subset of cancers.

Spécificité

Expected to react with spliced isoforms 1, 3, and 4. Reactivity toward isoform 2 has not been determined.

Immunogène

GST-tagged recombinant protein corresponding to human Homeodomain-only Protein.

Application

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Nuclear Receptors

This Anti-Homeodomain-only Protein Antibody, clone 15C1.1 is validated for use in Western Blotting for the detection of Homeodomain-only Protein.

Qualité

Evaluated by Western Blotting in mouse lung tissue lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected Homeodomain-only Protein in 10 µg of mouse lung tissue lysate.

Description de la cible

~10 kDa observed. Uncharacterized band(s) may appear in some lysates.

Forme physique

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stockage et stabilité

Stable for 1 year at 2-8°C from date of receipt.

Autres remarques

Concentration: Please refer to lot specific datasheet.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable