MABC307

Anti-phospho-ULK1 (Ser 467), clone 15D12.3 Antibody

clone 15D12.3, from mouse

• Synonyme(s) : Serine/threonine-protein kinase ULK1, Autophagy-related protein 1 homolog, ATG1, hATG1, Unc-51-like kinase 1
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: mouse
• Niveau de qualité: 100
• Forme d'anticorps: purified antibody
• Type de produit anticorps: primary antibodies
• Clone: 15D12.3, monoclonal
• Espèces réactives: human
• Technique(s): western blot: suitable
• Isotype: IgMλ
• Numéro d'accès NCBI: NP_003556
• Numéro d'accès UniProt: O75385
• Conditions d'expédition: wet ice
• Modification post-traductionnelle de la cible: phosphorylation (pSer467)
• Informations sur le gène: human ... ULK1(8408)

Description

Description générale

ULK1 or autophagy-related protein 1 homolog (ATG1) is a serine/threonine protein kinase. It is a ubiquitously expressed protein that is highly abundant in the brain, skeletal muscle, and heart. It is involved in the signaling pathway of mTOR receptors leading to the regulation of autophagy in nutrient-deprived cells. mTOR may interact with ULK1 as a complex of ULK1/FIP200/Atg13. ULK1 may play an important role in neuronal development: Elimination of ULK1′s enzymatic activity by targeted disruption of its kinase domain has blocked the outgrowth of neurons in the developing mouse brain, possibly by blocking the ULK1-mediated trafficking of neurotrophins.

Immunogène

KLH-conjugated linear peptide corresponding to human phospho-ULK1 (Ser 467).

Application

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

This Anti-phospho-ULK1 (Ser 467) antibody, clone 15D12.3 is validated for use in western blotting for the detection of phospho-ULK1 (Ser 467).

Qualité

Evaluated by Western Blotting in A-431 serum starved cell lysate.

Western Blotting Analysis: 0.2 µg/mL of this antibody detected phospho-ULK1 (Ser467) in 10 µg of A-431 serum starved cell lysate.

Description de la cible

~112 kDa observed

Forme physique

Format: Purified

Protein G Purified

Purified mouse monoclonal IgMλ supernatant in buffer containing PBS with 0.05% sodium azide.

Stockage et stabilité

Stable for 1 year at 2-8°C from date of receipt.

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable