ABN418

Anti-TRPM4 Antibody

from rabbit, purified by affinity chromatography

• Synonyme(s) : Transient receptor potential cation channel subfamily M member 4, hTRPM4, Calcium-activated non-selective cation, channel 1, Long transient receptor potential channel 4, LTrpC-4, LTrpC4, Melastatin-4
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Produit purifié par: affinity chromatography
• Espèces réactives: human, rat
• Réactivité de l'espèce (prédite par homologie): mouse (based on 100% sequence homology), monkey (based on 100% sequence homology), chimpanzee (based on 100% sequence homology)
• Technique(s): immunohistochemistry: suitable; western blot: suitable
• Numéro d'accès NCBI: NP_060106
• Numéro d'accès UniProt: Q8TD43
• Conditions d'expédition: wet ice
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... TRPM4(54795)

Description

Description générale

TRPM4, also known as Calcium-activated non-selective cation channel 1, Long transient receptor potential channel 4, Melastatin-4 or LTrpC4, and encoded by the gene TRPM4/LTRPC4, is a calcium activated non-selective ion channel for Na+, K+, Cs+ and Li+ ions. TRPM4 plays a central role in membrane depolarization in cardiomyocytes, cortical and dorsal root neurons, endocrine cells, kidney epithelial cells and even hair cells. Additionally, TRPM4 participates in T-cell activation, IL-2 production, blood vessel constriction, insulin secretion and even cell proliferation in various cell types through the up regulation of the beta catenin signaling pathway. TRPM4 is localized to the cell membrane and golgi apparatus and endoplasmic reticulum. TRPM4 is widely expressed. Defects in TRPM4 may be associated with progressive familial heart block disorder which can be a fatal though unpredictable syndrome.

Immunogène

BCP-conjugated linear peptide corresponding to human TRPM4 near the N-terminal.

Application

Anti-TRPM4 Antibody detects level of TRPM4 & has been published & validated for use in TRPM4.

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected TRPM4 in human cerebellum and human prostate tissue.

Qualité

Evaluated by Western Blotting in human cerebellum tissue lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected TRPM4 in 10 µg of human cerebellum tissue lysate.

Description de la cible

~150 kDa observed. Uniprot describes 2 isoforms produced by alternative splicing at ~130 kDa and ~147 kDa

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable