AB10140

Anti-Drebrin A/E Antibody

from rabbit, purified by affinity chromatography

• Synonyme(s) : Developmentally-regulated brain protein, drebrin 1, drebrin E, drebrin E2
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Produit purifié par: affinity chromatography
• Espèces réactives: rat, human, mouse
• Technique(s): immunocytochemistry: suitable; western blot: suitable
• Numéro d'accès NCBI: NM_004395.3
• Numéro d'accès UniProt: Q07266
• Conditions d'expédition: wet ice
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... DBN1(1627)

Description

Description générale

The developmentally-regulated neuron-specific protein, Drebrin A, is expressed first at the time of outgrowth and maturation of dendrites, and is localized within dendrites of the adult brain. Drebrin E+A- signals have been observed in the cell bodies of migrating neuroblasts in the core region; however, only fibrous and punctate drebrin E+A- signals were observed in postmigratory neuroblasts at the outer layers. Studies have demonstrated that the disappearance of drebrin E+A- signals from the cell body coincides with the cessation of neuronal migration. The disappearance of drebrin E from the cell body may be a molecular switch for the cessation of migration in newly generated neuroblast

Spécificité

Cat. # AB10140 detects the internal domain of Drebrin A/E.

May react with human based on sequence homology. Reactivity with other species has not been determined.

Immunogène

Epitope: Internal Domain

KLH conjugated synthetic linear peptide.

Application

Detect Drebrin A/E using this Anti-Drebrin A/E Antibody validated for use in WB & IC.

Immunocytochemistry: Proven to react with Drebrin A/E in 16 DIV rat cortical neurons. Photo courtesy of Dr. Gang Lui, Drexel University.

Research Category
Neuroscience

Research Sub Category
Synapse & Synaptic Biology

Qualité

Western Blot:
A 1:5,000 dilution of this antibody was used to detect embryonic rat brain (day 16) tissue lysate.

Description de la cible

~77 kDa

Forme physique

Antigen Affinity Purified

Purified rabbit polyclonal antibody in PBS with 0.05% NaN3.

Stockage et stabilité

Stable for 1 year at 2-8ºC from date of receipt.

Remarque sur l'analyse

Control
Embryonic rat brain (day 16) tissue lysate.

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable