681674

Wnt Pathway Inhibitor XI, CCT036477

The Wnt Pathway Inhibitor XI, CCT036477, also referenced under CAS 305372-78-5, controls the biological activity of Wnt Pathway. This small molecule/inhibitor is primarily used for Cancer applications.

• Synonyme(s) : Wnt Pathway Inhibitor XI, CCT036477, CCT036477, CRT Inhibitor VI, β-Catenin/Tcf Inhibitor VI
• Formule empirique (notation de Hill): C₂₁H₁₈ClN₃
• Numéro CAS: 305372-78-5
• Poids moléculaire : 347.84
• Numéro MDL: MFCD01831143
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95% (¹H-NMR)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: off-white
• Solubilité: DMSO: 50 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C
• InChI: 1S/C21H18ClN3/c1-14-20(17-6-2-3-7-18(17)24-14)21(15-9-11-16(22)12-10-15)25-19-8-4-5-13-23-19/h2-13,21,24H,1H3,(H,23,25)
• Clé InChI: IFOHRIXRQPOHQZ-UHFFFAOYSA-N

Description

Description générale

A cell-permeable indole derivative that acts as an inhibitor of Wnt signaling and exhibits an inhibitory effect in a reporter cell line (IC₅₀ = 4.6 µM) and demonstrates growth inhibition in multiple cancer cell lines, not by altering β-catenin accumulation but by blocking transcription at the β-catenin level. Displays reduced expression of Wnt target genes in myc and survivin-luciferase reporter assays, and exhibits in vivo activity by blocking the development of zebrafish at 20 µM and Xenopus embryos at 75 µM.

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following recontitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Ewan, K., et al. 2010. Cancer Res.70, 5963.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2