553590

Ratjadone A

InSolution, ≥95%, Synthetic

• Synonyme(s) : InSolution Ratjadone A, Synthetic, Ratjadon, Chromosome Region Maintenance 1 Protein Inhibitor II, CRM1 Inhibitor II, Exportin 1 Inhibitor II, XPO1 Inhibitor II
• Formule empirique (notation de Hill): C₂₈H₄₀O₅
• Numéro CAS: 163564-92-9
• Poids moléculaire : 456.61
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95% (HPLC)
• Forme: liquid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Solubilité: aqueous buffer: ≤100 μM; methanol: 20 mg/mL
• Conditions d'expédition: wet ice
• Température de stockage: −70°C
• InChI: 1S/C28H40O5/c1-6-9-26-22(5)25(30)18-27(33-26)24(29)12-7-10-19(2)16-21(4)17-20(3)14-15-23-11-8-13-28(31)32-23/h6-10,12-15,17,21-27,29-30H,11,16,18H2,1-5H3/b9-6+,12-7+,15-14+,19-10+,20-17-/t21-,22+,23-,24-,25-,26+,27+/m1/s1
• Clé InChI: CAYGMWMWJUFODP-AYFTZVAISA-N

Description

Description générale

A cell-permeable polyketide that displays potent anti-tumor properties in eukaryotes. Originally identified as a metabolite from the myxobacterium Sorangium cellulosum for its antibiotic activities against yeast and filamentous fungi. Ratjadones act by inhibiting nuclear export of LR-NES (leucine rich-nuclear export signal)-containing proteins by covalently binding to CRM1. Inhibits proliferation (IC₅₀ ≤1 ng/ml) and induces cell cycle arrest at the G1 phase.

A cell-permeable polyketide that displays potent antitumor properties in eukaryotes. Originally identified as a metabolite from the myxobacterium Sorangium cellulosum for its antibiotic activities against yeasts and filamentous fungi, ratjadones inhibit nuclear export of LR-NES (leucine rich-nuclear export signal)-containing proteins by covalently binding to CRM1. Inhibits proliferation (IC₅₀ ≤ 1 ng/ml) and induces cell cycle arrest at G1 phase.

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
nuclear export of LR-NES

Product does not compete with ATP.

Reversible: no

Target IC₅₀: ≤ 1 ng/ml for inhibiting proliferation and inducing cell cycle arrest at G1 phase

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Flammable (J)

Forme physique

A 5 µg/ml solution (2 µg in 400 µl) in methanol.

Reconstitution

Following initial thaw, aliquot and freeze (-70°C).

Autres remarques

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Köster, M., et al. 2003. Exp. Cell Res.286, 321.
Kalesse, M., et al. 2001. Chem biochem2, 709.
Gerth, K., et al. 1995. J. Antibiot.48, 973.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS02,GHS06,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H225,H301 + H311 + H331,H370
• Conseils de prudence: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• Classification des risques: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Organes cibles: Eyes,Central nervous system
• Code de la classe de stockage: 3 - Flammable liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): 49.5 °F
• Point d'éclair (°C): 9.7 °C