552233

QX-314

≥99% (HPLC), lyophilized solid, voltage-sensitive Na+ conductance blocker, Calbiochem^®

• Synonyme(s) : QX-314
• Formule empirique (notation de Hill): C₁₆H₂₇BrN₂O
• Numéro CAS: 21306-56-9
• Poids moléculaire : 343.30
• Numéro MDL: MFCD00083182
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• product name: QX-314, A quaternary lidocaine derivative, permanently charged, and lipophobic.
• Niveau de qualité: 100
• Pureté: ≥99%
• Forme: lyophilized solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Solubilité: water: 3 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 10-30°C
• InChI: 1S/C16H26N2O/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5/h9-11H,6-8,12H2,1-5H3/p+1
• Clé InChI: PYEBKOFMWAMBFV-UHFFFAOYSA-O

Description

Description générale

A quaternary lidocaine derivative, permanently charged, and lipophobic. A powerful blocker of voltage-sensitive Na⁺ conductance when applied intracellularly. Suppresses the generation of Na⁺-dependent spikes from inside the cell membrane, without affecting Ca²⁺ currents or glutamate-activated currents.

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
A powerful blocker of voltage-sensitive Na+ conductance

Product does not compete with ATP.

Reversible: no

fully active in neurophysiological testing

Avertissement

Toxicity: Irritant (B)

Autres remarques

Mooney, R. 1992. J. Neurosci.12, 2464.
Regehr, W.G. and Tank, D.W. 1992. J. Neurosci.12, 4202.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable