520219

PPACK II trifluoroacetate salt

≥95% (HPLC), solid, kallikrein inhibitor, Calbiochem^®

• Synonyme(s) : PPACK II, Trifluoroacetate Salt
• Formule empirique (notation de Hill): C₂₅H₃₃ClN₆O₃ · 2C₂HF₃O₂
• Numéro CAS: 74392-49-7
• Poids moléculaire : 729.07
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• product name: PPACK II, Trifluoroacetate Salt, Potent and specific irreversible inhibitor of plasma and glandular kallikreins.
• Niveau de qualité: 100
• Pureté: ≥95% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated
• Couleur: off-white
• Solubilité: water: 100 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C
• InChI: 1S/C25H33ClN6O3/c26-16-22(33)20(12-7-13-30-25(28)29)31-21(15-18-10-5-2-6-11-18)24(35)32-23(34)19(27)14-17-8-3-1-4-9-17/h1-6,8-11,19-21,31H,7,12-16,27H2,(H4,28,29,30)(H,32,34,35)/t19-,20+,21+/m1/s1
• Clé InChI: UFXAQJOOAQICNE-HKBOAZHASA-N

Description

Description générale

Potent and specific irreversible inhibitor of plasma and glandular kallikreins. Also available as a 10 mM solution in H₂O (Cat. No. 508573).

Potent and specific irreversible inhibitor of plasma and glandular kallikreins. Inhibits the cleavage of atrial naturiuretic peptide (ANP 1-126) by kallikreins. Also inhibits adrenal kininogenase, a kallikrein-like enzyme.

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
Plasma and glandular kallikreins

Product does not compete with ATP.

Reversible: no

Avertissement

Toxicity: Standard Handling (A)

Séquence

H-D-Phe-Phe-Arg-chloromethylketone, 2TFA

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

Autres remarques

Byrne, R.E., and Scanu, A.M. 1989. J. Lipid Res. 30, 109.
Scicli, G., et al. 1989. Adv. Exp. Med. Biol.247B, 217.
Gibson, T.R., et al. 1987. Endocrinology120, 764.
Kettner, G., and Shaw, E. 1981. Methods Enzymol.80, 826.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable