5.05378

IKK Inhibitor VII

InSolution, ≥97%, 10 mM in DMSO, potent, selective, and ATP-competitive inhibitor of IKK

• Synonyme(s) : InSolution IKK Inhibitor VII, (4-(4-(Benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)phenyl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone, InSolution IKK Inhibitor VII, IKK 16, IKK 16, (4-(4-(Benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)phenyl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone, InSolution IKK Inhibitor VII
• Formule empirique (notation de Hill): C₂₈H₂₉N₅OS
• Numéro CAS: 873225-46-8
• Poids moléculaire : 483.63
• Code UNSPSC : 12352200

Propriétés

• Niveau de qualité: 100
• Pureté: ≥97% (HPLC)
• Forme: liquid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; avoid repeated freeze/thaw cycles; desiccated (hygroscopic); protect from light
• Température de stockage: −70°C
• InChI: 1S/C28H29N5OS/c34-27(33-17-12-23(13-18-33)32-15-3-4-16-32)20-7-9-22(10-8-20)30-28-29-14-11-24(31-28)26-19-21-5-1-2-6-25(21)35-26/h1-2,5-11,14,19,23H,3-4,12-13,15-18H2,(H,29,30,31)
• Clé InChI: BWZJBXAPRCVCKQ-UHFFFAOYSA-N

Description

Description générale

A cell-permeable benzamido-pyrimidine compound that acts as a potent, selective, and ATP-competitive inhibitor of IKK (IC₅₀ = 40, 70, and 200 nM for IKK-2, IKK complex, and IKK-1, respectively). Inhibits cellular IκBα degradation and NF-κB-mediated gene expression in vitro in HUVEC cells and has been shown to exhibit excellent in vivo efficacy both in mice and rats.

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
IKK-2, IKK complex, and IKK-1

Reversible: yes

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Irritant (B)

Forme physique

A 10 mM (500 µg/103 µL) sterile-filtered solution of IKK Inhibitor VII (Cat. No. 401486) in DMSO.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.

Autres remarques

Waelchli, R., et al. 2006. Bioorg. Med. Chem. Lett.16, 108.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany