454861

MNK1 Inhibitor

The MNK1 Inhibitor, also referenced under CAS 522629-08-9, controls the biological activity of MNK1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonyme(s) : MNK1 Inhibitor, 4-Amino-5-(4-fluoroanilino)-pyrazolo[3,4-d]pyrimidine, CGP 57380, MNK Inhibitor I, Mitogen-Activated Protein Kinase-Interacting Kinase Inhibitor I
• Formule empirique (notation de Hill): C₁₁H₉FN₆
• Numéro CAS: 522629-08-9
• Poids moléculaire : 244.23
• Numéro MDL: MFCD03861062
• Code UNSPSC : 12352200

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: off-white
• Solubilité: DMSO: 15 mg/mL; ethanol: 5 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C
• InChI: 1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18)
• Clé InChI: UQPMANVRZYYQMD-UHFFFAOYSA-N

Description

Description générale

A cell-permeable, reversible, and ATP-competitive pyrazolo-pyrimidine compound that acts as a selective inhibitor of mitogen-activated protein kinase-interacting kinase 1 (MNK1; IC₅₀ = 2.2 µM) with no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases. Effectively inhibits eIF4E phosphorylation (IC₅₀ = 3 µM) by MNK1 in 293 human embryonic kidney cells and serves as a useful tool in studying MNK1-mediated cellular signaling.

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
Mitogen-activated protein kinase-interacting kinase 1 (MNK1)

Product competes with ATP.

Reversible: yes

Target IC₅₀: 2.2 µM against mitogen-activated protein kinase-interacting kinase 1 (MNK1); 3 µM against eIF4E phosphorylation by MNK1 in 293 human embryonic kidney cells

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Toxic (F)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Autres remarques

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Topisirovic, I., et al. 2004. Cancer Res.64, 8639.
Worch, J., et al. 2004. Oncogene23, 9162.
Walsh, D., and Mohr, I. 2004. Genes Dev.18, 660.
Morley, S.J., and Naegele, S. 2002. J. Biol. Chem.277, 32855.
Knauf, U., et al. 2001. Mol. Cell. Biol.21, 5500.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3