454586

NMDAR2C/2D Inhibitor, DQP-1105

The NMDAR2C/2D Inhibitor, DQP-1105 controls the biological activity of NMDAR2C/2D. This small molecule/inhibitor is primarily used for Neuroscience applications.

• Synonyme(s) : NMDAR2C/2D Inhibitor, DQP-1105, NMDA Antagonist IV, DQP-1105
• Formule empirique (notation de Hill): C₂₉H₂₄BrN₃O₄
• Numéro CAS: 380560-89-4
• Poids moléculaire : 558.42
• Numéro MDL: MFCD02989065
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥97% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: yellow-white
• Solubilité: DMSO: 10 mg/mL, pale yellow
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• Chaîne SMILES: O=C(O)CCC(N1N=C(C2=C(C3=CC=CC=C3)C4=C(NC2=O)C=CC(C)=C4)CC1C5=CC=C(Br)C=C5)=O

Description

Description générale

A dihydroquinilone-pyrazoline NMDA antagonist, which is selective for NMDA receptors that are comprised of recombinant subunits GluN1/GluN2C (IC₅₀ = 5.4 µM) and GluN1/GluN2D (2.2 µM) over GluN1/GluN2B (206 µM) and GluN1/ClucN2A (undetectable) in Xenopus oocytes. Similar selectivity is observed in whole-cell HEK patch-clamp assays with IC₅₀ values for GluN2C and GluN2D that are at least 50-fold lower than those for recombinant GluN2A, GluN2B, GluA1, or GluK2-containing receptors. It inhibits NMDA by blocking a conformational change necessary for channel opening and is non-competitive with co-agonists, glutamate and glycine.

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Regulatory Review (Z)

Autres remarques

Acker, T., et al. 2011. Mol. Pharmacol.80, 782.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable