444288

MMP-2 Inhibitor III

The MMP-2 Inhibitor III, also referenced under CAS 704888-90-4, controls the biological activity of MMP-2. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• Synonyme(s) : MMP-2 Inhibitor III, (2-((Isopropoxy)-(1,1ʹ-biphenyl-4-ylsulfonyl)-amino))-N-hydroxyacetamide
• Formule empirique (notation de Hill): C₁₇H₂₀N₂O₅S
• Numéro CAS: 704888-90-4
• Poids moléculaire : 364.42
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: white
• Solubilité: methanol: 100 mg/mL; DMSO: 200 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C
• InChI: 1S/C17H20N2O5S/c1-13(2)24-19(12-17(20)18-21)25(22,23)16-10-8-15(9-11-16)14-6-4-3-5-7-14/h3-11,13,21H,12H2,1-2H3,(H,18,20)
• Clé InChI: PHGLPDURIUEELR-UHFFFAOYSA-N

Description

Description générale

A cell-permeable biphenylsulfonamido-hydroxamate compound that acts a potent and Zn²⁺-binding site-targeting inhibitor of MMP-2 (IC₅₀ = 12 nM). It exhibits good selectivity over MMP-9 and MMP-3 (IC₅₀ = 0.2 and 4.5 µM, respectively) and shows practically no effect towards MMP-1 and MMP-7 (IC₅₀ >50 µM). Shown to effectively suppress the invasiveness of HT1080 sarcoma cells grown on matrigel.

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
MMP-2

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 12 nM against MMP-2

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Irritant (B)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Autres remarques

Tuccinardi, T., et al. 2006. Bioorg. Med. Chem.14, 4260.
Rossello, A., et al. 2004. Bioorg. Med. Chem.12, 2441.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable