420136

JNK Inhibitor IX

The JNK Inhibitor IX, also referenced under CAS 312917-14-9, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonyme(s) : JNK Inhibitor IX, N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-1-naphthamide
• Formule empirique (notation de Hill): C₂₀H₁₆N₂OS · xH₂O
• Numéro CAS: 312917-14-9
• Poids moléculaire : 332.42 (anhydrous basis)
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: tan
• Solubilité: DMSO: 10 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C
• InChI: 1S/C20H16N2OS/c21-12-17-15-9-3-4-11-18(15)24-20(17)22-19(23)16-10-5-7-13-6-1-2-8-14(13)16/h1-2,5-8,10H,3-4,9,11H2,(H,22,23)
• Clé InChI: WQGDQGAFSDMBLA-UHFFFAOYSA-N

Description

Description générale

A thienylnaphthamide compound that acts as a potent and ATP binding site-targeting inhibitor of JNK2 and JNK3 (pIC₅₀ = 6.5 and 6.7, respectively) with little or no activity against JNK1, p38α, and a panel of more than 30 other kinases (pIC₅₀<5.0). In contrast, SP600125 offers little selectivity between JNK1 and JNK3 (pIC₅₀ = 6.4 and 5.9, respectively) under the same assay conditions.

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
JNK2 and JNK3

Product competes with ATP.

Reversible: no

pIC50 = 6.5 and 6.7, against JNK2 and JNK3, respectively

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Irritant (B)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Autres remarques

Angell, R.M., et al. 2007. Bioorg. Med. Chem. Lett.17, 1296.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable