401116
Human IgG, Fab Fragment, Plasma
Synonyme(s) :
IgG Fab fragment
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About This Item
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.77
Produits recommandés
Pureté
≥95% (SDS-PAGE)
Niveau de qualité
Forme
liquid
Fabricant/nom de marque
Calbiochem®
Conditions de stockage
OK to freeze
Solubilité
sterile distilled water: soluble
Conditions d'expédition
ambient
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Description générale
Immunoglobulin G (IgG) is the most crucial glycoprotein antibody. It has the longest serum half-life compared to other immunoglobulins. IgG is present in human serum and also identified in the bloodstream. It contains four polypeptide chains, wherein the light and heavy chains are linked by disulfide bonds.
Application
Human IgG, Fab Fragment, Plasma has been used in enzyme-linked immunosorbent assay (ELISA).
Actions biochimiques/physiologiques
Immunoglobulin G (IgG) initiates the classical pathway of the complement system and eliminates virus particles and toxins. It controls antibody-dependent cell-mediated cytotoxicity (ADCC) and might be correlated to allergy. Digestion of IgG by papain generates fragment antigen-binding (Fab) whereas pepsin digestion of IgG releases crystallizable (Fc) fragment and a single dimeric F(ab)2. Maternal IgG is transferred to the fetus via the placenta and is crucial for the immune defense of the neonate against infections. IgG levels in severe acute respiratory syndrome coronavirus (SARS-CoV)2 infected patients may be useful to understand the severity and prognosis of coronavirus disease 2019 (COVID-19).
Avertissement
Toxicity: Standard Handling (A)
Forme physique
In 150 mM NaCl, 20 mM sodium phosphate buffer, 0.05% NaN₃, pH 7.4.
Notes préparatoires
Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies of HIV and HCV.
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Informations légales
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Clause de non-responsabilité
Ce produit, destiné à la recherche scientifique, est soumis à une réglementation spécifique en France, y compris pour les activités d′importation et d′exportation (Article L 1211-1 alinéa 2 du Code de la Santé Publique). L′acheteur (c′est-à-dire l′utilisateur FINAL) est tenu d′obtenir une autorisation d′importation auprès du ministère français de la recherche, mentionné à l′article L1245-5-1 II du Code de la Santé Publique. En commandant ce produit, vous confirmez détenir l′autorisation d′importation requise.
Code de la classe de stockage
12 - Non Combustible Liquids
Classe de danger pour l'eau (WGK)
nwg
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
S G Johansson et al.
Allergy, 56(9), 813-824 (2001-09-12)
This report has been prepared by an EAACI task force representing the five EAACI Sections and the EAACI Executive Committee composed of specialists that reflect the broad opinion on allergy expressed by various clinical and basic specialties dealing with allergy.
Harry W Schroeder et al.
The Journal of allergy and clinical immunology, 125(2 Suppl 2), S41-S52 (2010-03-05)
Immunoglobulins are heterodimeric proteins composed of 2 heavy and 2 light chains. They can be separated functionally into variable domains that bind antigens and constant domains that specify effector functions, such as activation of complement or binding to Fc receptors.
Hongyan Hou et al.
Clinical & translational immunology, 9(5), e01136-e01136 (2020-05-10)
This study aimed to determine the IgM and IgG responses against severe acute respiratory syndrome coronavirus (SARS-CoV)-2 in coronavirus disease 2019 (COVID-19) patients with varying illness severities. IgM and IgG antibody levels were assessed via chemiluminescence immunoassay in 338 COVID-19
Gestur Vidarsson et al.
Frontiers in immunology, 5, 520-520 (2014-11-05)
Of the five immunoglobulin isotypes, immunoglobulin G (IgG) is most abundant in human serum. The four subclasses, IgG1, IgG2, IgG3, and IgG4, which are highly conserved, differ in their constant region, particularly in their hinges and upper CH2 domains. These
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