400011

Caspase-1 Inhibitor I, Cell-Permeable

The Caspase-1 Inhibitor I, Cell-Permeable controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications.

• Synonyme(s) : Caspase-1 Inhibitor I, Cell-Permeable, ICE Inhibitor I, Cell-permeable, YVAD-CHO, Cell-permeable, Ac-AAVALLPAVLLALLAPYVAD-CHO
• Formule empirique (notation de Hill): C₉₇H₁₆₀N₂₀O₂₄
• Poids moléculaire : 1990.43
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥97% (HPLC)
• Forme: solid
• Puissance: 1 nM K_i
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze
• Couleur: white
• Solubilité: DMSO: 5 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: −20°C

Description

Description générale

A cell-permeable inhibitor of caspase-1 (ICE; Interleukin-1β Converting Enzyme), caspase-4, and caspase-5. The C-terminal YVAD-CHO sequence of this peptide is a highly specific, potent, and reversible inhibitor of caspase-1 (K_i = 1 nM). The N-terminal sequence (amino acid residues 1-16) corresponds to the hydrophobic region (h-region) of the signal peptide of the Kaposi fibroblast growth factor (K-FGF) and confers cell-permeability to the peptide.

A cell-permeable inhibitor of caspase-1 (ICE; interleukin-1β converting enzyme). The C-terminal YVAD-CHO sequence of this peptide is a highly specific, potent, and reversible inhibitor of caspase-1 (K_i = 1 nM). The N-terminal sequence (residues 1-16) corresponds to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF) and confers cell-permeability to the peptide.

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
Caspase-1

Product does not compete with ATP.

Reversible: yes

Avertissement

Toxicity: Standard Handling (A)

Séquence

Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Tyr-Val-Ala-Asp-CHO

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Autres remarques

Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Lin, Y.-Z., et al. 1996. J. Biol. Chem.271, 5305.
Lin, Y.-Z., et al. 1995. J. Biol. Chem.270, 14255.
Reiter, L.A. 1994. Int. J. Pept. Protein Res.43, 87.
Thornberry, N.A., et al. 1994. Biochemistry33, 3934.
Thornberry, N.A., et al. 1994. MethodsEnzymol. 244, 615.
Thornberry, N.A., et al. 1992. Nature 356, 768.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable