344911

Fura-2 LR/AM

Acetoxymethyl (AM) derivative of FURA-PE3 with spectral properties similar to the parent compound.

• Synonyme(s) : Fura-2 LR/AM, Fura-2 Leakage Resistant (AM)
• Formule empirique (notation de Hill): C₅₅H₆₃N₅O₂₉
• Numéro CAS: 172890-84-5
• Poids moléculaire : 1258.10
• Numéro MDL: MFCD00285848
• Code UNSPSC : 12171500
• Nomenclature NACRES : NA.25

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95% (HPLC)
• Forme: gum
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: light yellow
• Solubilité: DMSO: 10 mg/mL
• Fluorescence: λ_ex 368 nm (low); λ_ex 374 nm (high); λ_em 518 nm (low); λ_em 524 nm (high)
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• InChI: 1S/C55H63N5O29/c1-33(61)76-27-82-49(68)22-57-11-13-58(14-12-57)48(67)10-8-39-7-9-41(59(23-50(69)83-28-77-34(2)62)24-51(70)84-29-78-35(3)63)44(17-39)74-15-16-75-45-18-40-19-46(54-56-21-47(89-54)55(73)87-32-81-38(6)66)88-43(40)20-42(45)60(25-52(71)85-30-79-36(4)64)26-53(72)86-31-80-37(5)65/h7,9,17-21H,8,10-16,22-32H2,1-6H3
• Clé InChI: CGAZNAYDEAJZHQ-UHFFFAOYSA-N

Description

Description générale

Acetoxymethyl (AM) derivative of FURA-PE3 with spectral properties similar to the parent compound. Can be loaded into cells in a manner similar to FURA 2/AM. Hydrolysis by non-specific esterases traps the indicator in the cytosol. Compared to FURA-2, it is retained longer in the cell. Note: 1 set = 10 x 50 µg.

An acetoxymethyl (AM) derivative of FURA-PE3. with spectral properties similar to the parent compound. Can be loaded into cells in a manner similar to FURA 2/AM (Cat. No. 344905). Hydrolysis by non-specific esterases traps the indicator in the cytosol. Spectral properties in the presence of low calcium concentrations (ex. 364 nm, em. 508 nm) differ from those during high calcium conditions (ex. 335 nm, em. 495 nm). Note: 1 set = 10 x 50 µg.

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
Calcium Probes

Product does not compete with ATP.

Reversible: no

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Autres remarques

Abe, F., et al. 1995. Br. J. Pharmacol.116, 3000.
Vorndran, C., et al. 1995. Biophys. J.69, 2114.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable