325001

Epothilone B, Synthetic

A structural analog of Epothilone A with similar biological properties.

• Synonyme(s) : Epothilone B, Synthetic, EpoB
• Formule empirique (notation de Hill): C₂₇H₄₁NO₆S
• Numéro CAS: 152044-54-7
• Poids moléculaire : 507.68
• Numéro MDL: MFCD02101921
• Code UNSPSC : 12352200

Propriétés

• Niveau de qualité: 100
• Pureté: ≥99% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: white to off-white
• Solubilité: DMSO: 10 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• InChI: 1S/C27H41NO6S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)33-23(30)13-21(29)26(5,6)25(32)17(3)24(15)31/h11,14-15,17,20-22,24,29,31H,8-10,12-13H2,1-7H3/b16-11+/t15-,17+,20-,21-,22-,24-,27+/m0/s1
• Clé InChI: QXRSDHAAWVKZLJ-PVYNADRNSA-N

Description

Description générale

A structural analog of Epothilone A (Cat. No. 325000) with similar biological properties. However, EpoB is about 10-fold more potent than EpoA against P-glycoprotein-expressing multidrug resistant (MDR) cells (IC₅₀ = 2 nM for MDR CCRF-CEM/VBL₁₀₀ cells).

A structural analog of Epothilone A (Cat. No. 325000) with similar biological properties. However, EpoB is about 10-fold more potent than EpoA against P-glycoprotein-expressing multi drug resistant (MDR) cells (IC₅₀ = 2 nM for MDR CCRF-CEM/VBL₁₀₀ cells).

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
P-glycoprotein-expressing multidrug resistant (MDR) cells

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 2 nM for MDR CCRF-CEM/VBL100 cells

Avertissement

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.

Autres remarques

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Giannakakou, P., et al. 2000. Proc. Natl. Acad. Sci. USA97, 2904.
Chou, T.-C., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 9642.
Kowalski, R.J., et al. 1997. J. Biol. Chem. 272, 2534.
Muhlradt, P.F., and Sasse, F. 1997. Cancer Res. 57, 3344.
Nicolaou, K.C., et al. 1997. Nature 387, 268.
Bollag, D.M., et al. 1995. Cancer Res. 55, 2325.

Informations légales

Not available for sale in Germany.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable