288500-M

DL-α-Difluoromethylornithine, Hydrochloride

A cell-permeable, anticancer agent that acts as a specific and irreversible inhibitor of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis.

• Synonyme(s) : DL-α-Difluoromethylornithine, Hydrochloride, DFMO, Eflornithine, RMI-71782
• Formule empirique (notation de Hill): C₆H₁₂F₂N₂O₂ · xHCl · yH₂O
• Numéro CAS: 96020-91-6
• Poids moléculaire : 182.17 (anhydrous free base basis)
• Code UNSPSC : 12352200

Propriétés

• Niveau de qualité: 100
• Pureté: ≥99% (TLC)
• Forme: powder
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated (hygroscopic)
• Couleur: white
• Solubilité: water: 1 mg/mL; methanol: 25 mg/mL
• Température de stockage: 10-30°C
• InChI: 1S/C6H12F2N2O2.ClH.H2O/c7-4(8)6(10,5(11)12)2-1-3-9;;/h4H,1-3,9-10H2,(H,11,12);1H;1H2
• Clé InChI: FJPAMFNRCFEGSD-UHFFFAOYSA-N

Description

Description générale

A cell-permeable, anticancer agent that acts as a specific and irreversible inhibitor of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis. Inhibits B16 melanoma-induced angiogenesis in ovo and proliferation of vascular endothelial cells in vitro.

A cell-permeable, anticancer agent that acts as a specific and irreversible inhibitor of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis. Inhibits B16 melanoma-induced angiogenesis in ovo and proliferation of vascular endothelial cells in vitro.

Actions biochimiques/physiologiques

Primary Target
ODC

Avertissement

Toxicity: Carcinogenic / Teratogenic (D)

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Meyskens, F.L., Jr., and Gerner, E.W. 1995. J. Cell. Biochem. (Suppl.) 22, 126.
Feuerstein, B.G., et al. 1992. Cancer Res. 52, 6782.
Takigawa, M., et al. 1990. Cancer Res.50, 4131.
Weeks, C.E., et al. 1982. Proc. Natl. Acad. Sci. USA 79, 6028.
Danzin, C., et al. 1979. Life Sci. 24, 519.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable