203984

2,3-Butanedione 2-Monoxime

An inhibitor of skeletal and cardiac muscle contraction.

• Synonyme(s) : 2,3-Butanedione 2-Monoxime, BDM
• Formule empirique (notation de Hill): C₄H₇NO₂
• Numéro CAS: 57-71-6
• Poids moléculaire : 101.10
• Numéro MDL: MFCD00002116
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (GC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated (hygroscopic)
• Couleur: white to off-white
• Solubilité: methanol: 100 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C
• InChI: 1S/C4H7NO2/c1-3(5-7)4(2)6/h7H,1-2H3/b5-3+
• Clé InChI: FSEUPUDHEBLWJY-HWKANZROSA-N

Description

Description générale

An inhibitor of skeletal and cardiac muscle contraction. A "chemical phosphatase" that dephosphorylates acetylcholinesterase poisoned with organophosphates. Inhibits Ca²⁺ currents in adult rat cervical ganglion in a reversible and dose-dependent manner (IC₅₀ = 18.3 nM). Also shown to induce Ca²⁺ release from canine cardiac sarcoplasmic reticulum (SR).

An inhibitor of skeletal and cardiac muscle contraction. A general reversible inhibitor of myosin ATPase in eukaryotes. A “chemical phosphatase,” which dephosphorylates acetylcholinesterase poisoned with organophosphates. Inhibits Ca²⁺ currents in adult rat cervical ganglion in a reversible and dose-dependent manner (IC₅₀ = 18.3 nM). Also shown to induce Ca²⁺ release from canine cardiac sarcoplasmic reticulum (SR).

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
Ca²⁺ currents in adult rat cervical ganglion in a reversible and dose-dependent manner

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 18.3 nM inhibiting Ca2+ currents in adult rat cervical ganglion in a reversible and dose-dependent manner

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Phillips, R.M., and Altschuld, R.A. 1996. Biochem. Biophys. Res. Commun.229, 154.
Sellin, L.C., and McArdle, J.J. 1994. Pharmacol. Toxicol.74, 305.
Zhu, Y., and Ikeda, S.R. 1993. Neurosci.Lett. 155, 24.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable