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2011

Millipore

Bilirubin

solid, bile pigment, Calbiochem®

Synonyme(s) :

Bilirubin

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About This Item

Formule empirique (notation de Hill):
C33H36N4O6
Numéro CAS:
635-65-4
Poids moléculaire :
584.66
Numéro MDL:
MFCD00005499
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77

product name

Bilirubin, Principal pigment of bile and one of the major end products of hemoglobin decomposition.

Niveau de qualité

100

Forme

solid

Fabricant/nom de marque

Calbiochem®

Conditions de stockage

OK to freeze
protect from light

Couleur

red-brown

Solubilité

chloroform: 1 mg/mL
alkaline solution: soluble

Conditions d'expédition

ambient

Température de stockage

10-30°C

InChI

1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/b26-13-,27-14-

Clé InChI

BPYKTIZUTYGOLE-IFADSCNNSA-N

Description générale

Bilirubin is an orange-yellow bile pigment and one of the major end products of hemoglobin decomposition. It contains conjugated double bonds and reactive hydrogen atoms. In adults, the upper limit of the normal range of bilirubin is >1mg/dL. Serum levels of bilirubin in healthy newborns are less than 15 mg/dl. This product corresponds to the unconjugated form.

Actions biochimiques/physiologiques

Bilirubin is reported to cross the blood-brain barrier and exert significant antioxidant effects in the brain. This pigment aids in coloration in the various forms of jaundice. Bilirubin levels act as biomarkers in liver and blood disorders. Unconjugated form of bilirubin at lower levels serves as a physiological antioxidant. However, increased concentration of bilirubin is toxic and leads to neonatal hyperbilirubinemia in neonates.

Reconstitution

Unstable in basic solutions; reconstitute just prior to use.

Autres remarques

Extinction coefficient (454 nm, CHCl3):59,100-62,300 M-1cm-1.
Cell permeable: no
Reversible: no
Product does not compete with ATP.
Primary Target

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

What's in a name? Physiologic and pathologic jaundice: the conundrum of defining normal bilirubin levels in the newborn.
M Jeffrey Maisels
Pediatrics, 118(2), 805-807 (2006-08-03)
Elisabeth Lobner et al.
Frontiers in bioengineering and biotechnology, 8, 49-49 (2020-03-03)
The transmembrane protein CD19 is exclusively expressed on normal and malignant B cells and therefore constitutes the target of approved CAR-T cell-based cancer immunotherapies. Current efforts to assess CAR-T cell functionality in a quantitative fashion both in vitro and in
Zeng Hong et al.
ACS omega, 5(46), 29903-29912 (2020-12-01)
The reaction of magnesium or zinc amides with alkyl or benzyl halides is an attractive approach to make C-N bonds, especially for electron-poor organic halides. The magnesium-promoted preparation of hindered non-nucleophilic amine (N,N-diisopropylethylamine) from ethyl chloride and zinc diisopropylamide has
Sana Ullah et al.
Iranian journal of public health, 45(5), 558-568 (2016-07-12)
Hyperbilirubinemia, or jaundice, is a life threatening disorder in newborns. It is a multifactorial disorder with many symptoms. Generally, the physiological jaundice is the most prevalent type however in some regions pathological jaundice is also common. This review article focuses
R Stocker et al.
Science (New York, N.Y.), 235(4792), 1043-1046 (1987-02-27)
Bilirubin, the end product of heme catabolism in mammals, is generally regarded as a potentially cytotoxic, lipid-soluble waste product that needs to be excreted. However, it is here that bilirubin, at micromolar concentrations in vitro, efficiently scavenges peroxyl radicals generated
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