14-548-M

MSK1 Protein, active, 10 µg

Active, N-terminal His6-tagged recombinant human MSK1 residues 2-end, for use in Kinase Assays.

• Code UNSPSC : 12352202
• eCl@ss : 32160405
• Nomenclature NACRES : NA.32

Propriétés

• Source biologique: human
• Niveau de qualité: 100
• Produit recombinant: expressed in baculovirus infected Sf21 cells
• Gamme de produits: Upstate^®
• Activité spécifique: (For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.)
• Poids mol.: M_w 94 kDa
• Produit purifié par: (Ni²⁺/NTA-agarose)
• Espèces réactives: human
• Fabricant/nom de marque: Upstate^®
• Technique(s): activity assay: suitable (kinase)
• Numéro d'accès: (FUNCTION: SwissProt: O75582 # Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of ′Ser-1′ of histone H2A. Phosphorylates ′Ser-10′ of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate ′Ser-28′ of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14). ); NM_004755.2
• Numéro d'accès NCBI: NM_004755.2; NM_182398.1
• Numéro d'accès UniProt: O75582
• Maladie(s) pertinente(s): metabolic disorders; cardiovascular diseases
• Informations sur le gène: human ... RPS6KA5(9252)

Description

Description générale

N-terminal His6-tagged recombinant human MSK1 residues 2-end

Application

Research Category
Metabolism

Research Sub Category
Cardiovascular Disease

Metabolic Disorders

Actions biochimiques/physiologiques

Protein Target: MSK1

Target Sub-Family: AGC

Conditionnement

Also available in 10 μg size and in bulk

Also available in 250 µg size --call for pricing and availability and reference catalog number 14-548M when ordering the 250 µg size.

Qualité

routinely evaluated by phosphorylation of Crosstide

Description de la cible

MSK1

Forme physique

Ni²⁺/NTA-agarose

Stockage et stabilité

6 months at -20°C

Autres remarques

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Informations légales

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H317
• Conseils de prudence: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Classification des risques: Skin Sens. 1
• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1