112251

α₁-Acid Glycoprotein, Human Plasma

• Synonyme(s) : α₁-Acid Glycoprotein, Human Plasma, α₁-AG, C-AGP, Orosomucoid, α₁M-Seromucoid
• Numéro CAS: 66455-27-4
• Numéro MDL: MFCD00131224
• Code UNSPSC : 12352202

Propriétés

• Source biologique: human plasma
• Niveau de qualité: 100
• Pureté: ≥95% (SDS-PAGE)
• Forme: lyophilized
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze
• Solubilité: aqueous buffer: 1 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C

Description

Description générale

Native α₁-acid glycoprotein from human plasma. Glycoprotein used for the study of the structure of oligosaccharide units. Consists of 40 - 45% carbohydrate. Present in human plasma at concentrations of 55 - 140 mg/100 ml. Clinically,α₁-AG is an acute-phase reactant that, together with haptoglobin, indicates acute inflammation. Selectively suppresses the augmentation of NK cell activity by IFN-α and IFN-γ. Theα₁-AG:α₁-antitrypsin ratio is useful in diagnosis of liver disease. A sialic acid-deficientα₁-AG has been observed in serum or urine of patients with Hodgkin’s disease, psoriatic arthritis, diabetes, and chronic myeloid leukemia. Sialic acid-deficientα₁-AG has an affinity for vitamin B₁₂.

Native α₁-acid glycoprotein from human plasma. Glycoprotein used for the study of the structure of oligosaccharide units. Consists of 40-45% carbohydrate. Present in human plasma at concentrations of 55-140 mg/100 ml. Clinically, α₁-AG is an acute phase reactant that, together with haptoglobin, indicates acute inflammation. Selectively suppresses the augmentation of NK cell activity by IFN-α and IFN-γ. The α₁-AG:α₁-antitrypsin ratio is useful in diagnosis of liver disease. A sialic acid-deficient α₁-AG has been observed in serum or urine of patients with Hodgkin′s disease, psoriatic arthritis, diabetes, and chronic myeloid leukemia. Sialic acid-deficient α₁-AG has an affinity for vitamin B₁₂.

Avertissement

Toxicity: Standard Handling (A)

Notes préparatoires

Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for to 3 months at (-20°C).

Autres remarques

Aso, H., et al. 1999. Inflammation 23, 117.
Schmid, K., et al. 1973. Biochemistry 12, 2711.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Ce produit, destiné à la recherche scientifique, est soumis à une réglementation spécifique en France, y compris pour les activités d′importation et d′exportation (Article L 1211-1 alinéa 2 du Code de la Santé Publique). L′acheteur (c′est-à-dire l′utilisateur FINAL) est tenu d′obtenir une autorisation d′importation auprès du ministère français de la recherche, mentionné à l′article L1245-5-1 II du Code de la Santé Publique. En commandant ce produit, vous confirmez détenir l′autorisation d′importation requise.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable