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05-747

Sigma-Aldrich

Anti-phospho-MEK1 (Ser218/222)/MEK2 (Ser222/226) Antibody, rabbit monoclonal

Upstate®, from rabbit

Synonyme(s) :

Anti-CFC3, Anti-MAPKK1, Anti-MEK1, Anti-MEL, Anti-MKK1, Anti-PRKMK1

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Forme d'anticorps

purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

monoclonal

Espèces réactives

human, mouse, rat

Fabricant/nom de marque

Upstate®

Technique(s)

western blot: suitable

Isotype

IgG

Numéro d'accès NCBI

NM_002755
NM_030662

Numéro d'accès UniProt

Q02750

Conditions d'expédition

dry ice

Modification post-traductionnelle de la cible

phosphorylation (pSer218/pSer222)

Informations sur le gène

human ... MAP2K1(5604)

Spécificité

phosphorylated MEK1/MEK2

Immunogène

Peptide containing DpSMANpSF in which pS corresponds to phosphorylated amino acids 218 and 222 of human MEK1

Application

Detect phospho-MEK1 (Ser218/222)/MEK2 (Ser222/226) using this Anti-phospho-MEK1 (Ser218/222)/MEK2 (Ser222/226) Antibody validated for use in WB.
Research Category
Signaling
Research Sub Category
MAP Kinases

Qualité

routinely evaluated by immunoblot on RIPA lysates from PC-12 cells that have been treated with B-Raf

Description de la cible

45kDa

Liaison

Replaces: 04-1017

Forme physique

0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Format: Purified
Protein A purified

Stockage et stabilité

2 years at -20°C

Informations légales

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Negative regulation of MAPKK by phosphorylation of a conserved serine residue equivalent to Ser212 of MEK1.
Gopalbhai, Kailesh, et al.
The Journal of Biological Chemistry, 278, 8118-8125 (2003)
Gonzalo L Gonzalez-Del Pino et al.
Proceedings of the National Academy of Sciences of the United States of America, 118(36) (2021-09-03)
The RAF/MEK/ERK pathway is central to the control of cell physiology, and its dysregulation is associated with many cancers. Accordingly, the proteins constituting this pathway, including MEK1/2 (MEK), have been subject to intense drug discovery and development efforts. Allosteric MEK
C Hodge et al.
The Journal of biological chemistry, 273(47), 31327-31336 (1998-11-13)
Growth hormone (GH), a major regulator of normal body growth and metabolism, regulates cellular gene expression. The transcription factors Elk-1 and Serum Response Factor are necessary for GH-stimulated transcription of c-fos through the Serum Response Element (SRE). GH stimulates the
J C S Ho et al.
Oncogene, 35(7), 897-907 (2015-06-02)
HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) kills tumor cells broadly suggesting that conserved survival pathways are perturbed. We now identify nucleotide-binding proteins as HAMLET binding partners, accounting for about 35% of all HAMLET targets in a protein microarray
The 5-HT 2A serotonin receptor enhances cell viability, affects cell cycle progression and activates MEK-ERK1/2 and JAK2-STAT3 signalling pathways in human choriocarcinoma cell lines.
Oufkir T, Arseneault M, Sanderson JT, Vaillancourt C
Placenta null
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