04-290
Anti-EGFR (CT) Antibody, clone 13G8
clone 13G8, from mouse
Synonyme(s) :
ERBB, mENA, ERBB1
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About This Item
Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
mouse
Niveau de qualité
Forme d'anticorps
purified antibody
Type de produit anticorps
primary antibodies
Clone
13G8, monoclonal
Espèces réactives
mouse, human
Fabricant/nom de marque
Chemicon®
Upstate®
Technique(s)
ELISA: suitable
immunocytochemistry: suitable
western blot: suitable
Isotype
IgG1
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... EGFR(1956)
mouse ... Egfr(13649)
Spécificité
Recognizes C-terminus domain of EGF receptor (aa1165-1186)
Immunogène
KLH-conjugated synthetic peptide encompassing the surrounding amino acids of the C terminus in human EGFR
Application
Anti-EGFR (C-terminus) Antibody, clone 13G8 detects level of EGFR (C-terminus) & has been published & validated for use in ELISA, IC & WB.
Research Category
Signaling
Signaling
Research Sub Category
Growth Factors & Receptors
Growth Factors & Receptors
Qualité
Routinely evaluated by immunoblot.
Description de la cible
180 kDa
Liaison
Replaces: 04-337; 04-338
Forme physique
100 µg of purified mouse monoclonal IgG lyophilized in PBS containing 0.09% sodium azide, PEG, and sucrose
Format: Purified
Subsequent thiophilic adsorption and size exclusion chromatography
Stockage et stabilité
2 years at -20°C from date of shipment
Remarque sur l'analyse
Control
Includes EGF treated Hep2G lysate as a positive control
Includes EGF treated Hep2G lysate as a positive control
Informations légales
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Tarif
Code de la classe de stockage
10 - Combustible liquids
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Xiaozhu Zhang et al.
Journal of medical genetics, 44(3), 166-172 (2006-12-13)
Frequent overexpression of epidermal growth factor receptor (EGFR) in non-small-cell lung cancer (NSCLC) makes EGFR a new therapeutic target. Two specific EGFR tyrosine kinase inhibitors, gefitinib (ZD1839, Iressa) and erlotinib (OSI-774, Tarceva), have been developed and approved by the US
Katsuyuki Hotta et al.
Oncology reports, 17(2), 313-317 (2007-01-05)
Despite its tremendous antitumor effect in a subset of patients with non-small cell lung cancer (NSCLC), the exact mechanism of gefitinib-induced cell death has not been fully determined. In this study, forms of cell death in various NSCLC cell lines
Francesca Walker et al.
Experimental cell research, 313(3), 511-526 (2006-12-13)
The site of action of growth factors on mammalian cell cycle has been assigned to the boundary between the G1 and S phases. We show here that Epidermal Growth Factor (EGF) is also required for mitosis. BaF/3 cells expressing the
Alexandra I Rosa et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(13), 4573-4584 (2010-04-02)
In the adult mammalian brain, the subventricular zone (SVZ) hosts stem cells constantly generating new neurons. Angiopoietin-1 (Ang-1) is an endothelial growth factor with a critical role in division, survival, and adhesion of endothelial cells via Tie-2 receptor activity. Expression
Jane Fraser et al.
EMBO reports, 20(10), e47734-e47734 (2019-08-27)
Despite recently uncovered connections between autophagy and the endocytic pathway, the role of autophagy in regulating endosomal function remains incompletely understood. Here, we find that the ablation of autophagy-essential players disrupts EGF-induced endocytic trafficking of EGFR. Cells lacking ATG7 or
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