Z-007

Zolpidem phenyl-4-carboxylic acid solution

500 μg/mL in acetonitrile: water (1:1), ampule of 1 mL, certified reference material, Cerilliant^®

• Numéro CAS: 109461-65-6
• Numéro MDL: MFCD18252339
• Code UNSPSC : 41116107
• ID de substance PubChem : 329831594
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: certified reference material
• Forme: liquid
• Caractéristiques: Snap-N-Spike^®/Snap-N-Shoot^®
• Conditionnement: ampule of 1 mL
• Fabricant/nom de marque: Cerilliant^®
• Concentration: 500 μg/mL in acetonitrile: water (1:1)
• Technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• Application(s): clinical testing
• Format: single component solution
• Température de stockage: −20°C
• Chaîne SMILES: CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c3ccc(cc3)C(O)=O
• InChI: 1S/C19H19N3O3/c1-12-4-9-16-20-18(13-5-7-14(8-6-13)19(24)25)15(22(16)11-12)10-17(23)21(2)3/h4-9,11H,10H2,1-3H3,(H,24,25)
• Clé InChI: FELZONDEFBLTSP-UHFFFAOYSA-N

Description

Description générale

Zolpidem Phenyl-4-carboxylic acid is the major urinary metabolite of zolpidem, accounting for 51% of an administered dose. Literature references indicate the metabolite can be found in urine for 2-3 days following ingestion of a single therapeutic dose of zolpidem. Zolpidem, marketed as Ambien^® or Stilnox^®, is a nonbenzodiazepine used for the short-term treatment of insomnia.

Application

• Pharmacokinetics in forensic contexts: A study demonstrated the simultaneous analysis of Zolpidem and its metabolites, including Zolpidem phenyl-4-carboxylic acid, in postmortem urine, which is critical for forensic toxicology (Yamaguchi et al., 2023).



• Detection in hair samples: Research developed a sensitive LC-MS/MS method for detecting picogram levels of Zolpidem and its primary metabolites, such as Zolpidem phenyl-4-carboxylic acid, in hair, offering valuable insights for forensic and clinical investigations (Kim et al., 2021).



• Advanced analytical techniques: The determination of Zolpidem phenyl-4-carboxylic acid and Zolpidem 6-carboxylic acid in hair was achieved using gas chromatography-electron ionization-tandem mass spectrometry, enhancing the capabilities of toxicological analyses (Kwon et al., 2021).



• Pharmacokinetic profiling: A study on the pharmacokinetics of Zolpidem and Zolpidem phenyl-4-carboxylic acid in oral fluid post administration provided crucial data for understanding drug behavior in therapeutic monitoring (Feng et al., 2019).



• Forensic case study: An examination of a fatal zolpidem poisoning case highlighted the postmortem distribution and redistribution of Zolpidem and its predominant metabolite, Zolpidem phenyl-4-carboxylic acid, in body fluids and tissues, offering insights for forensic pathology (Hasegawa et al., 2018).

Informations légales

Ambien is a registered trademark of Sanofi S.A.

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Stilnox is a registered trademark of Sanofi S.A.

Informations sur la sécurité

• Pictogrammes: GHS02,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H225,H302,H319
• Conseils de prudence: P210 - P233 - P240 - P241 - P301 + P312 - P305 + P351 + P338
• Classification des risques: Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
• Code de la classe de stockage: 3 - Flammable liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): 55.4 °F - closed cup
• Point d'éclair (°C): 13 °C - closed cup