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O-023

Supelco

Oxazepam glucuronide solution

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Formule empirique (notation de Hill):
C21H19ClN2O8
Numéro CAS:
6801-81-6
Poids moléculaire :
462.84
Numéro CE :
200-659-6
Numéro MDL:
MFCD00872000
Code UNSPSC :
41116107
ID de substance PubChem :
329818831

Qualité

certified reference material

Forme

liquid

Caractéristiques

Snap-N-Spike®/Snap-N-Shoot®

Conditionnement

ampule of 1 mL

Fabricant/nom de marque

Cerilliant®

drug control

Narcotic Licence Schedule B (Switzerland)

Concentration

100 μg/mL in methanol

Technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

Application(s)

clinical testing

Format

single component solution

Température de stockage

−20°C

Chaîne SMILES 

O[C@@H]1[C@@H](O)[C@H](OC2N=C(c3ccccc3)c4cc(Cl)ccc4NC2=O)O[C@@H]([C@H]1O)C(O)=O

InChI

1S/C21H19ClN2O8/c22-10-6-7-12-11(8-10)13(9-4-2-1-3-5-9)24-19(18(28)23-12)32-21-16(27)14(25)15(26)17(31-21)20(29)30/h1-8,14-17,19,21,25-27H,(H,23,28)(H,29,30)/t14-,15-,16+,17-,19?,21-/m0/s1

Clé InChI

FIKQKGFUBZQEBL-IFBJMGMISA-N

Description générale

Oxazepam glucuronide is a major urinary metabolite of the benzodiazepine drug, oxazepam. Oxazepam, marketed as Alepam, Medopam, or Murelax®, has been used extensively since the 1960s for treatment of anxiety and insomnia and in the control of symptoms of alcohol withdrawal. This certified reference solution is suitable for GC/MS or LC/MS applications with oxazepam or oxazepam glucuronide such as urine drug testing, pain prescription monitoring, toxicology analysis, or forensic testing.

Application


  • Advanced Analytical Techniques for Benzodiazepine Metabolites: Oxazepam glucuronide has been targeted in studies using high-performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS). This method allows for the sensitive and automatic determination of diazepam and its metabolites, including oxazepam glucuronide, in human oral fluid, highlighting its utility in forensic and clinical toxicology (Jiang et al., 2016).

  • Forensic Applications: Oxazepam glucuronide is directly determined using μElution solid-phase extraction and liquid chromatography-tandem mass spectrometry (LC-MS/MS) in human whole blood. This technique is crucial for forensic science, providing reliable data for legal and medical investigations involving benzodiazepine use (Wang et al., 2013).

Informations légales

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Murelax is a registered trademark of Aspen Pharma Pty Ltd
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Pictogrammes

FlameSkull and crossbonesHealth hazard
GHS02,GHS06,GHS08

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Organes cibles

Eyes

Code de la classe de stockage

3 - Flammable liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

49.5 °F - closed cup

Point d'éclair (°C)

9.7 °C - closed cup

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

M V St-Pierre et al.
Journal of pharmacokinetics and biopharmaceutics, 18(5), 423-448 (1990-10-01)
The disposition of tracer doses of 3H-oxazepam was studied in the recirculating perfused mouse liver preparation. 3H-Oxazepam was biotransformed primarily to the diastereomeric 3H-oxazepam glucuronides, which either effluxed into the circulation or underwent biliary excretion. Three additional, unknown metabolites constituted
Beitske E Smink et al.
British journal of clinical pharmacology, 66(4), 556-560 (2008-07-30)
To measure and compare the concentration-time profiles of oxazepam and oxazepam glucuronide in blood, serum and oral fluid within the scope of roadside testing. Biological samples were collected from eight male subjects after ingestion of 15 or 30 mg oxazepam
J Sonne et al.
European journal of clinical pharmacology, 35(4), 385-389 (1988-01-01)
Six healthy volunteers received oxazepam 15 mg i.v. and orally at an interval of at least one week. The kinetic variables of i.v. oxazepam were: elimination half-life (t1/2 beta) 6.7 h, total clearance (CL) 1.07 ml.min-1.kg-1, volume of distribution (Vc)
A M van Hecken et al.
British journal of clinical pharmacology, 20(3), 225-234 (1985-09-01)
Single dose pharmacokinetics of oxazepam, 30 mg, have been studied in six healthy male volunteers in the absence of diflunisal and during continuous treatment with diflunisal 500 mg twice daily. During diflunisal treatment, peak plasma concentration of oxazepam significantly decreased
S F Sisenwine et al.
Drug metabolism and disposition: the biological fate of chemicals, 10(6), 605-608 (1982-11-01)
The concentrations of (R)-(-)- and (S)-(+)-oxazepam glucuronides in plasma and urine of several species have been measured. The relative amounts of these diastereoisomers vary among species. Thus, in the plasma and urine of rhesus monkeys the concentrations of the R-isomer
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Protocoles

Using UHPLC/MS (TOF) for Detection of Drugs and Metabolites in Urine Following Optimized Enzymatic Hydrolysis Conditions

To optimize hydrolysis using β-glucuronidase, factors such as incubation time, temperature, hydrolysis pH, enzyme source, and enzyme concentration must be evaluated for each glucuronide metabolite to be analyzed.

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