N-045

Norbuprenorphine glucuronide solution

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• Synonyme(s) : Norbuprenorphine glucuronide solution
• Formule empirique (notation de Hill): C₃₁H₄₃NO₁₀
• Numéro CAS: 469887-29-4
• Poids moléculaire : 589.67
• Numéro CE : 200-659-6
• Numéro MDL: MFCD08275612
• Code UNSPSC : 41116107
• ID de substance PubChem : 329818436
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: certified reference material
• Forme: liquid
• Caractéristiques: Snap-N-Spike^®/Snap-N-Shoot^®
• Conditionnement: ampule of 1 mL
• Fabricant/nom de marque: Cerilliant^®
• Concentration: 100 μg/mL in methanol
• Technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• Application(s): forensics and toxicology
• Format: single component solution
• Température de stockage: −20°C
• Chaîne SMILES: CO[C@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]4Cc5ccc(O[C@@H]6O[C@@H]([C@@H](O)[C@H](O)[C@H]6O)C(O)=O)c7O[C@@H]2[C@]3(CCN4)c57
• InChI: 1S/C31H43NO10/c1-27(2,3)28(4,38)16-13-29-8-9-31(16,39-5)26-30(29)10-11-32-17(29)12-14-6-7-15(22(42-26)18(14)30)40-25-21(35)19(33)20(34)23(41-25)24(36)37/h6-7,16-17,19-21,23,25-26,32-35,38H,8-13H2,1-5H3,(H,36,37)/t16-,17-,19+,20+,21-,23+,25-,26-,28+,29-,30+,31-/m1/s1
• Clé InChI: OOLGGESLZHGXGC-TXYLTYGDSA-N

Description

Description générale

This analytical reference standard is applicable for use in LC/MS or GC/MS applications for pain prescription monitoring, urine drug testing, clinical toxicology, or forensic analysis. Norbuprenorphine glucuronide is a urinary metabolite of the semi-synthetic opioid analgesic buprenorphine. Buprenorphine, sold under the trade names Temgesic and Subutex^®, is prescribed for the treatment of chronic pain and heroin addiction.

Application

• Reference material in mass spectrometry: Norbuprenorphine glucuronide is employed as a reference standard in mass spectrometry to facilitate the quantification of buprenorphine and its metabolites in human plasma. This application is essential for monitoring therapeutic drug levels during opioid addiction treatments, highlighting its role in improving the precision of pharmacokinetic assessments (Zhao et al., 2024).
• Opioid metabolite analysis: The compound serves a critical role in the analytical assessment of urine samples for the presence of opioid metabolites, aiding in the development of more robust forensic and clinical toxicology methods. Such applications underscore its importance in the context of substance abuse monitoring and management (Furo et al., 2024).

Informations légales

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Subutex is a registered trademark of RB Pharmaceuticals Limited

Informations sur la sécurité

• Pictogrammes: GHS02,GHS06,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H225,H301 + H311 + H331,H370
• Conseils de prudence: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Classification des risques: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Organes cibles: Eyes
• Code de la classe de stockage: 3 - Flammable liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): 49.5 °F - closed cup
• Point d'éclair (°C): 9.7 °C - closed cup