810270P
Avanti
C11 TopFluor™ Ceramide-1-Phosphate
N-[11-(dipyrrometheneboron difluoride)undecanoyl]-D-erythro-sphingosine-1-phosphate (ammonium salt), powder
Synonyme(s) :
N-[11-(TopFluor)undecanoyl]-D-ceramide-1-phosphate (ammonium salt)
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About This Item
Formule empirique (notation de Hill):
C42H74BF2N4O6P
Numéro CAS:
Poids moléculaire :
810.84
Code UNSPSC :
12352211
Nomenclature NACRES :
NA.25
Produits recommandés
Pureté
>99% (TLC)
Forme
powder
Conditionnement
pkg of 1 × 250 μg (810270P-250ug)
Fabricant/nom de marque
Avanti Research™ - A Croda Brand 810270P
Conditions d'expédition
dry ice
Température de stockage
−20°C
Catégories apparentées
Description générale
Ceramide-1-phosphate (C1P), an anti-apoptotic lipid is produced with the help of ceramide kinase (CERK) by the direct phosphorylation of ceramide.
The availability of this new fluorescent metabolite provides the researcher with new ways to track cell migration and G protein coupled activity.
Application
C11 TopFluor™ Ceramide-1-Phosphate may be used to study its effect on the migration of pancreatic cancer stem cells (PCSC) using confocal microscopy.
Actions biochimiques/physiologiques
Ceramide-1-phosphate (C1P) is capable of blocking cell death in bone marrow-derived macrophages (BMDMs). It controls the growth and survival in various cell types. C1P bioactive sphingolipid is known to modulate the proliferation and differentiation of photoreceptors. C1P controls apoptosis. It acts as a pro-inflammatory agent and plays a key role in phagocytosis. Ceramide-1-phosphate is well known as a second messenger and an important mediator of inflammatory response.
Conditionnement
5 mL Amber Glass Screw Cap Vial (810270P-250ug)
Informations légales
Avanti Research is a trademark of Avanti Polar Lipids, LLC
TopFluor is a trademark of Avanti Polar Lipids, LLC
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Certificats d'analyse (COA)
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Ceramide and ceramide 1-phosphate in health and disease
Arana L, et al.
Lipids in Health and Disease, 9(1), 1-12 (2010)
The Role of Ceramide-1-Phosphate in Biological Functions
Handbook of Experimental Pharmacology, 153-153 (2013)
Ceramide-1-Phosphate, a New Mediator of Development and Survival in Retina Photoreceptors
Miranda GE, et al.
Investigative Ophthalmology & Visual Science, 52(9), 6580-6588 (2011)
Ceramide-1-phosphate in cell survival and inflammatory signaling
Gomez MA, et al.
Advances in Experimental Medicine and Biology, 118-130 (2010)
Carolyn M Shirey et al.
Chemistry and physics of lipids, 200, 32-41 (2016-10-26)
Ceramide-1-phosphate (C1P) is an important signaling sphingolipid and a metabolite of ceramide. C1P contains an anionic phosphomonoester head group and has been shown to regulate physiological and pathophysiological processes such as cell proliferation, inflammation, apoptosis, phagocytosis, and macrophage chemotaxis. Despite
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