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Key Documents

791641C

Avanti

15:0-18:1-d7-PI

Avanti Research - A Croda Brand

Synonyme(s) :

1-pentadecanoyl-2-oleoyl(d7)-sn-glycero-3-phosphoinositol (ammonium salt)

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About This Item

Formule empirique (notation de Hill):
C42H75D7NO13P
Numéro CAS:
Poids moléculaire :
847.12
Code UNSPSC :
12352211
Nomenclature NACRES :
NA.25

Pureté

>99% (TLC)

Forme

liquid

Conditionnement

pkg of 1 × 1 mL (791641C-1mg)

Fabricant/nom de marque

Avanti Research - A Croda Brand

Concentration

1 mg/mL (791641C-1mg)

Conditions d'expédition

dry ice

Température de stockage

−20°C

Description générale

15:0-18:1-d7-PI (1-pentadecanoyl-2-oleoyl(d7)-sn-glycero-3-phosphoinositol) is a deuterated phospholipid. The lipid comprises the phosphotidylinositol attached to pentadecanoic acid and oleic acid. Oleic acid harbors the deuterium ions. Phosphotidylinositol are esterified inositol associated with bacteria and eukaryotes. It is synthesized in endoplasmic reticulum and is an anionic lipid. The sn-1 and sn-2 positions of the glycerol is esterified with fatty acids. The phosphate group is present in sn-3 position.
This deuterium labeled lipid is also available in a formulation of multiple lipid standards. The SPLASH LIPIDOMIX Standard includes all of the major lipid classes at ratios relative to human plasma, allowing one easy internal standard solution to be added to every sample. [

Application

15:0-18:1-d7-PI (1-pentadecanoyl-2-oleoyl(d7)-sn-glycero-3-phosphoinositol (ammonium salt)) has been used:
  • as a component of extraction solvent for lipid isolation from biological samples
  • as an internal standard to spike cell lysate and to quantify lipid species using fourier transform mass spectrometry (FTMS) analysis
  • as an isotopically labeled lipid internal standard for correction of lipids detected in lipid droplets using shotgun mass spectrometry analysis

Actions biochimiques/physiologiques

Phosphotidylinositol (PI) undergo phosphorylation in their hydroxyls group and the phosphorylated PIs regulate various biological processes including membrane trafficking, endocytosis and autophagy.

Conditionnement

2 mL Amber Glass Sealed Ampule (791641C-1mg)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC
LIPIDOMIX is a trademark of Avanti Polar Lipids, LLC
SPLASH is a trademark of Avanti Polar Lipids, LLC

Pictogrammes

Skull and crossbonesHealth hazard

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

Organes cibles

Central nervous system, Liver,Kidney

Code de la classe de stockage

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

does not flash

Point d'éclair (°C)

does not flash


Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Robin F Irvine
Journal of lipid research, 57(11), 1987-1994 (2016-11-03)
The diverse family of inositol lipids is now known to be central to many aspects of cell biology. The route from the first discovery of inositol to our present day knowledge of inositol lipids spans more than 150 years and
Nicholas J Blunsom et al.
Biochimica et biophysica acta. Molecular and cell biology of lipids, 1865(1), 158471-158471 (2019-06-08)
Phosphatidylinositol (PI) is a minor phospholipid with a characteristic fatty acid profile; it is highly enriched in stearic acid at the sn-1 position and arachidonic acid at the sn-2 position. PI is phosphorylated into seven specific derivatives, and individual species
Tong Liu et al.
Expert review of proteomics, 17(3), 233-242 (2020-04-21)
Background: Colorectal cancer (CRC) represents a third leading cause of cancer-related death worldwide. The reliable diagnostic biomarkers for detecting CRC at early stage is critical for decreasing the mortality.Method: A conjunctive lipidomic approach was employed to investigate the differences in
Chuchu Wang et al.
Nature communications, 11(1), 1531-1531 (2020-03-27)
Vesicle associated membrane protein 2 (VAMP2/synaptobrevin2), a core SNARE protein residing on synaptic vesicles (SVs), forms helix bundles with syntaxin-1 and SNAP25 for the SNARE assembly. Prior to the SNARE assembly, the structure of VAMP2 is unclear. Here, by using

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