700042P

4β-hydroxycholesterol-d7

Avanti Research^™ - A Croda Brand

• Synonyme(s) : cholest-5-ene-3b,4b-diol(d7)
• Formule empirique (notation de Hill): C₂₇H₃₉O₂D₇
• Numéro CAS: 1246302-80-6
• Poids moléculaire : 409.70
• Code UNSPSC : 12352100
• Nomenclature NACRES : NA.25

Propriétés

• Description: cholest-5-ene-3,4-diol-d7
• Pureté: >99% (TLC)
• Forme: powder
• Conditionnement: pkg of 1 × 1 mg (700042P-1mg)
• Fabricant/nom de marque: Avanti Research^™ - A Croda Brand
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• InChI: 1S/C27H46O2/c1-17(2)7-6-8-18(3)20-11-12-21-19-9-10-23-25(29)24(28)14-16-27(23,5)22(19)13-15-26(20,21)4/h10,17-22,24-25,28-29H,6-9,11-16H2,1-5H3/t18-,19+,20-,21+,22+,24+,25-,26-,27-/m1/s1/i1D3,2D3,17D
• Clé InChI: CZDKQKOAHAICSF-BZNWTYAPSA-N

Description

Description générale

4β-hydroxycholesterol (4β-HC) is a catabolic product of cholesterol metabolism mediated by the enzyme cytochrome P450 family 3 subfamily A member 4 (CYP3A4). 4β-hydroxycholesterol-d7 is the deuterated form of 4β-hydroxycholesterol.

Application

4β-hydroxycholesterol-d7 has been used:

• as an internal standard to spike plasma samples ultra-high-pressure liquid,chromatography–tandem mass spectrometry (UHPLC-MS/MS) analysis
• to spike serum samples for mass spectrometry measurements
• as an internal standard for the quantification of human colon biopsies samples using HPLC-MS

Actions biochimiques/physiologiques

4β-hydroxycholesterol (4β-HC) may function as a liver X receptor ligand. The levels of 4β-HC are elevated in dextran sulfate induced colitis along with other oxysterols and it may promote colon inflammation.

Conditionnement

5 mL Amber Glass Screw Cap Vial (700042P-1mg)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids