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D2388

Sigma-Aldrich

Dimethyl 3,3′-dithiopropionimidate dihydrochloride

powder

Synonyme(s) :

DTBP, Dimethyl 3,3′-dithio-bis(propionimidate) dihydrochloride, Wang/Richards’ reagent

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About This Item

Formule empirique (notation de Hill):
C8H16N2O2S2 · 2HCl
Numéro CAS:
38285-78-8
Poids moléculaire :
309.28
Numéro MDL:
MFCD00043245
Code UNSPSC :
12352116
ID de substance PubChem :
57654084
Nomenclature NACRES :
NA.22

Forme

powder

Niveau de qualité

100

Pertinence de la réaction

reagent type: cross-linking reagent

Solubilité

H2O: 50 mg/mL

Température de stockage

2-8°C

Chaîne SMILES 

Cl.Cl.COC(=N)CCSSCCC(=N)OC

InChI

1S/C8H16N2O2S2.2ClH/c1-11-7(9)3-5-13-14-6-4-8(10)12-2;;/h9-10H,3-6H2,1-2H3;2*1H

Clé InChI

CQBCVFHLZAVNPF-UHFFFAOYSA-N

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Catégories apparentées

Application

Reactant for:
  • Synthesis of glutathione-sensitive cross-linked polyethylenimine gene vector
  • Preparation of cyclodextrin-containing polymers designed for gene delivery
  • Crosslinking of chick oviduct progesterone-receptor subunits

Attention

The reagant is readily hydrolyzed at neutral pH. Avoid use of reducing agents during coupling reactions.

Autres remarques

Note that the amidine linkage preserves original primary amine positive charge. The disulfide linkage is cleavable by mild reduction. Incorporates an eight atom linker.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H315

Classification des risques

Skin Irrit. 2

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Choong Eun Jin et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 5(10), 1800614-1800614 (2018-10-26)
Cell-free nucleic acids (cfNAs) are emerging diagnostic biomarkers for monitoring the treatment and recurrence of cancers. In particular, the biological role and clinical usefulness of cfNAs obtained from the plasma of patients with various cancers are popular and still intensely
Carine F Djuika et al.
Scientific reports, 7(1), 4410-4410 (2017-07-02)
Artemisinins are the current mainstay of malaria chemotherapy. Their exact mode of action is an ongoing matter of debate, and several factors have recently been reported to affect an early stage of artemisinin resistance of the most important human malaria
Xiaoqiang Liu et al.
The Analyst, 136(24), 5204-5210 (2011-10-19)
An ultrasensitive electrochemical immmunosensor was demonstrated to be capable of detecting the hormone cortisol down to concentrations as low as 16 pg mL(-1). In addition, the immunosensor displayed a sensitivity of 1.6 μA pg(-1) mL(-1) and a linear range up
R A Aman et al.
The Journal of biological chemistry, 260(11), 6966-6973 (1985-06-10)
Glycosomes, the microbody-like organelles containing mainly glycolytic enzymes, were purified from the long slender bloodstream form of Trypanosoma brucei EATRO 110 monomorphic strain by an improved method in which the protozoa were frozen and thawed in 15% glycerol to free
K K Sharma et al.
Experimental eye research, 61(4), 413-421 (1995-10-01)
Alpha crystallin can function as a molecular chaperone in suppressing the heat-induced aggregation of other crystallins and proteins. During cataractogenesis, alpha-crystallin becomes a water-insoluble, high-molecular-weight, cross-linked aggregate. To determine whether the chaperone activity of alpha crystallin is lost during this
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