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Merck
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Key Documents

934607

Sigma-Aldrich

Microneedle template

6x6 array, H 1000 μm, base size 250 μm, 1000µm pitch

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About This Item

Code UNSPSC :
42142600
Nomenclature NACRES :
NA.21

Hauteur

1000 μm

Taille de la base

250 μm

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Description générale

Microneedles are a platform for transdermal drug delivery. The advantages of microneedles include the delivery of large molecules, painless and less invasive adminsitration of the active pharmaceutical ingredient (API), ease of administration, and improved drug delivery including dose, delivery rate and efficacy. Microneedies are also effective for vaccine delivery due to the abundance of immune cells in the dermis. These microneedle templates can be used to make reproducible and high quality microneedle patches for a variety of therapuetics.

Application

Transdermal delivery of a variety to therapeutics including:

  • Nucleic acid delivery
  • Vaccine delivery
  • Protein or peptide delivery
  • Small molecule delivery

Caractéristiques et avantages

Microneedle templates are exclusively made for producing dissolvable microneedle patches with excellent qualitty and repeatability. These templates are made of silicone rubber which is extremely durable, and chemical and heat resistant.

Propriétés physiques

Microneedle template properties:
  • Silicone Template
  • Material: PDMS
  • Patch Size (D): 10mm x 10mm
  • Array Size: 6 x 6
  • Needle Height (A): 1000 µm
  • Needle Base (B): 250 µm
  • Needle Pitch (C): 1000 µm
  • Length of last microneedle cavity to the edge of the patch (F) can be calculated using the following formula: F = (patch size - [(n-1) x pitch)] / 2 where n = number of microneedles in one array
  • Sterilization: Autoclave (optional)
  • No. of use: repeated use if clean and stored properly

Autres remarques

Suggested instructions for use:

1. Ensure the microneedle template is clean by washing with mild soap and letting them air dry completely
2. Pipette a small quantity (50-100 µL) of the drug mixture onto the microneedle template
3. Subject the template to cenrifugal force for >60 seconds to ensure that alll microneedle cavities are completely filled. The speed and duration are proportional to the viscosity of the matrix material and the volume of microneedle cavities to fill. Complete filling can be confirmed by observing the microneedle cavities under microscope (20x). No air bubbles are present for complete filling.

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Consulter la Bibliothèque de documents

Jie Xu et al.
Molecules (Basel, Switzerland), 26(19), 5912-5912 (2021-10-14)
A microneedle (MN) is a painless and minimally invasive drug delivery device initially developed in 1976. As microneedle technology evolves, microneedles with different shapes (cone and pyramid) and forms (solid, drug-coated, hollow, dissolvable and hydrogel-based microneedles) have been developed. The

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