925632
Poly(ethylene glycol)-block-Poly(2-methacryloyloxyethyl phosphorylcholine)
PEG average Mn 5000, PMPC Mn 21,000
Synonyme(s) :
PEG-b-PMPC, PEG-PMPC
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About This Item
Formule linéaire :
CH3(C2H4O)nC6H7O2N(C11H22O6NP)
Code UNSPSC :
12352112
Nomenclature NACRES :
NA.23
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Application
PEG-b-PMPC is a biocompatible, non-fouling block copolymer composed of a neutral PEG block and a zwitterionic poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) block.
Poly (2-Methacryloyloxyethyl phosphorylcholine) (PMPC) is a methacrylate based polymer with a zwitterionic phosphorylcholine moiety on the side chain. The phosphorylcholine moiety is very similar to the head group of phospholipids in cell membranes. Due to this unique structure, PMPC showed excellent resistance to nonspecific protein adsorption, cell adhesion, and blood coagulation, as well as cell membrane penetration and underwater lubrication.
PMPC has been widely exploited in a diverse range of applications including
Poly (2-Methacryloyloxyethyl phosphorylcholine) (PMPC) is a methacrylate based polymer with a zwitterionic phosphorylcholine moiety on the side chain. The phosphorylcholine moiety is very similar to the head group of phospholipids in cell membranes. Due to this unique structure, PMPC showed excellent resistance to nonspecific protein adsorption, cell adhesion, and blood coagulation, as well as cell membrane penetration and underwater lubrication.
PMPC has been widely exploited in a diverse range of applications including
- antifouling materials for water treatment
- bioengineering
- nanomedicine
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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An introduction to zwitterionic polymer behavior and applications in solution and at surfaces.
Blackman L D, et al.
Chemical Society Reviews, 48, 757-757 (2019)
Andrew Lewis et al.
Bioconjugate chemistry, 19(11), 2144-2155 (2008-11-01)
The water-soluble, biocompatible polymer poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) was evaluated for protein conjugation. PMPC is a zwitterionic polymer that is able to form a more compact conformation in aqueous solution than poly(ethylene glycol) (PEG). While a terminally functionalized N-hydroxysuccinimide derivative of
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