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914827

Sigma-Aldrich

N6-((Prop-2-yn-1-yloxy)carbonyl)-L-lysine hydrochloride

≥98%

Synonyme(s) :

(S)-Amino-6-((prop-2-ynyloxy)carbonylamino)hexanoic acid hydrochloride, Clickable amino acid for bioconjugation, H-L-Lys(Poc)-OH HCl, Lysine-alkyne, Plk, Propargyl-derivatized lysize, UAA crosslinker

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About This Item

Formule empirique (notation de Hill):
C10H16N2O4 · xHCl
Numéro CAS:
1428330-91-9
Poids moléculaire :
228.25 (free base basis)
Code UNSPSC :
12352200

Pureté

≥98%

Forme

powder

Température de stockage

2-8°C

Application

N6-((Prop-2-yn-1-yloxy)carbonyl)-L-lysine hydrochloride is a clickable amino acid derivative for site-specific incorporation into recombinant proteins or synthesis of chemical probes and tools for biological applications. This non-canonical lysine possesses an alkyne for bioorthogonal reaction with azides.

Autres remarques

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PEGylated polylysine derived copolymers with reduction-responsive side chains for anticancer drug delivery

Construction of bacterial cells with an active transport system for unnatural amino acids

Semisynthesis of an Active Enzyme by Quantitative Click Ligation

Combined Use of Unnatural Amino Acids Enables Dual-Color Super-Resolution Imaging of Proteins via Click Chemistry

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Lot/Batch Number

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Robert Serfling et al.
Nucleic acids research, 46(1), 1-10 (2017-11-28)
The pyrrolysyl-tRNA synthetase/tRNAPyl pair is the most versatile and widespread system for the incorporation of non-canonical amino acids (ncAAs) into proteins in mammalian cells. However, low yields of ncAA incorporation severely limit its applicability to relevant biological targets. Here, we
Silvia Eger et al.
Methods in molecular biology (Clifton, N.J.), 832, 589-596 (2012-02-22)
The conjugation of poly-ubiquitin chains is a widespread post-translational modification of proteins that plays a role in many different cellular processes. Notably, the biological function of the attached ubiquitin chain depends on which lysine residue is used for chain formation.
Andreas Schmidt et al.
ACS chemical biology, 13(9), 2472-2483 (2018-08-01)
Single-molecule techniques allow unique insights into biological systems as they provide unrivaled access to structural dynamics and conformational heterogeneity. One major bottleneck for reliable single-molecule Förster resonance energy transfer (smFRET) analysis is the identification of suitable fluorophore labeling sites that
Ivana Nikić et al.
Angewandte Chemie (International ed. in English), 53(8), 2245-2249 (2014-01-30)
The growing demands of advanced fluorescence and super-resolution microscopy benefit from the development of small and highly photostable fluorescent probes. Techniques developed to expand the genetic code permit the residue-specific encoding of unnatural amino acids (UAAs) armed with novel clickable
Jihe Liu et al.
Journal of the American Chemical Society, 139(27), 9100-9103 (2017-06-29)
Site-specific incorporation of unnatural amino acids into proteins provides a powerful tool to study protein function. Here we report genetic code expansion in zebrafish embryos and its application to the optogenetic control of cell signaling. We genetically encoded four unnatural
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