910074

27,27-Dimethyl-25-oxo-3,6,9,12,15,18,26-heptaoxaoctacosanoic acid

≥95%

• Synonyme(s) : 2-2-2-2-2-2-6 PROTAC^® linker, Bifunctional linker, OtBu-PEG₆-acid
• Formule empirique (notation de Hill): C₂₃H₄₄O₁₀
• Poids moléculaire : 480.59
• Code UNSPSC : 12352106

Propriétés

• Pureté: ≥95%
• Forme: liquid
• Pertinence de la réaction: reagent type: linker
• Groupe fonctionnel: carboxylic acid; ester
• Température de stockage: 2-8°C
• Chaîne SMILES: O=C(CCCCCCOCCOCCOCCOCCOCCOCC(O)=O)OC(C)(C)C

Description

Application

This heterobifunctional, PEGylated crosslinker 27,27-dimethyl-25-oxo-3,6,9,12,15,18,26-heptaoxaoctacosanoic acid features a carboxyl group at one end and a t-butyl protected carboxylic acid at the other and exhibits both hydrophobic and hydrophilic moieties for use in biological applications. The linker can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or pproteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation where the linker region is referred to as 2-2-2-2-2-2-6.

Autres remarques

Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL

Technology Spotlight: Partial PROTACs for Targeted Protein Degradation

Informations légales

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable