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Key Documents

906611

Sigma-Aldrich

DLAM-MεVproS-13CH3 Methyl Labeling Kit

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About This Item

Code UNSPSC :
12352200
Nomenclature NACRES :
NA.12

Technique(s)

bio NMR: suitable

Niveau de qualité

200

Conditions d'expédition

dry ice

Température de stockage

−70°C

Description générale

DLAM-MεVproS-13CH3 Kit has 13CH3 isotopomer precursors and contains protocol instructions for creation of isotopically-labeled proteins.

Application

DLAM-MεVproS-13CH3 is an optimized kit to produce proteins with -13CH3 isotopomer on the methyl groups of methionine and valine residues. This kit has been tested with protein isotopic labeling in E. coli. It is used in TROSY NMR for revealing the mechanisms of dynamic molecular machines of N-terminal sequence
For detection of long-range nOes or for the NMR study of large proteins

Conditionnement

This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.

Pictogrammes

Corrosion
GHS05

Mention d'avertissement

Danger

Mentions de danger

H314

Classification des risques

Skin Corr. 1B

Code de la classe de stockage

8A - Combustible corrosive hazardous materials

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Tomasz L Religa et al.
Science (New York, N.Y.), 328(5974), 98-102 (2010-04-03)
The proteasome catalyzes the majority of protein degradation in the cell and plays an integral role in cellular homeostasis. Control over proteolysis by the 20S core-particle (CP) proteasome is achieved by gated access of substrate; thus, an understanding of the
Silke Wiesner et al.
Current opinion in structural biology, 35, 60-67 (2015-09-26)
Intermolecular interactions are indispensible for biological function. Here we discuss how novel NMR techniques can provide unique insights into the assembly, dynamics and regulation of biomolecular complexes. We focus on applications that exploit the methyl TROSY effect and show that

Articles

Methyl Isotope-Labeling of Proteins from NMR-Bio

Methyl groups are ideal probes for studying protein structure and function by NMR. Choose among user-friendly kits for isotope labeling of a single type or multiple types of methyl groups.

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

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