902691

Hydroxy-PEG5-t-butyl ester

• Synonyme(s) : tert-Butyl 1-hydroxy-3,6,9,12,15-pentaoxaoctadecan-18-oate, HO-PEG5-CO-OtBu
• Formule empirique (notation de Hill): C₁₇H₃₄O₈
• Numéro CAS: 850090-09-4
• Poids moléculaire : 366.45
• Numéro MDL: MFCD20926402
• Code UNSPSC : 51171641

Propriétés

• Pureté: ≥95%
• Forme: liquid
• Pertinence de la réaction: reagent type: cross-linking reagent
• Indice de réfraction: n/D 1.448
• Densité: 1.071
• Groupe fonctionnel: ester; hydroxyl
• Température de stockage: −20°C
• Chaîne SMILES: O=C(OC(C)(C)C)CCOCCOCCOCCOCCOCCO

Description

Application

This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophilic PEG linker facilitates solubility in biological applications. Hydroxy-PEG5-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

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Autres remarques

Synthesis and Application of Poly(phenylene Ethynylene)s for Bioconjugation: A Conjugated Polymer-Based Fluorogenic Probe for Proteases

Informations légales

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable