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900889

Sigma-Aldrich

Lithium phenyl-2,4,6-trimethylbenzoylphosphinate

≥95%

Synonyme(s) :

LAP

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About This Item

Formule empirique (notation de Hill):
C16H16LiO3P
Numéro CAS:
85073-19-4
Poids moléculaire :
294.21
Code UNSPSC :
12352128
Nomenclature NACRES :
NA.23

Niveau de qualité

100

Pureté

≥95%

Forme

crystalline powder

Couleur

white to off-white

Température de stockage

2-8°C

Chaîne SMILES 

CC1=C(C(P(C2=CC=CC=C2)(O[Li])=O)=O)C(C)=CC(C)=C1

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Application

Lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) is a water soluble, cytocompatible, Type I photoinitiator for use in the polymerization of hydrogels or other polymeric materials. This photoinitator is preferred over Irgacure 2959 for biological applications due to its increased water solubility, increased polymerization rates with 365 nm light, and absorbance at 400 nm allowing for polymerization with visible light. The improved polymerization kinetics enable cell encapsualation at reduced initiator concentration and longer wavelength light, which has been shown to reduce initiator toxicity and increase cell viability.

Caractéristiques et avantages

  • Superior water solubility
  • Biocompatible
  • Sensitiveto visible light

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Benjamin D Fairbanks et al.
Macromolecules, 44(8), 2444-2450 (2011-04-23)
Various techniques have been adopted to impart a biological responsiveness to synthetic hydrogels for the delivery of therapeutic agents as well as the study and manipulation of biological processes and tissue development. Such techniques and materials include polyelectrolyte gels that
Benjamin D Fairbanks et al.
Biomaterials, 30(35), 6702-6707 (2009-09-29)
Due to mild reaction conditions and temporal and spatial control over material formation, photopolymerization has become a valuable technique for the encapsulation of living cells in three dimensional, hydrated, biomimetic materials. For such applications, 2-hydroxy-1-[4-(2-hydroxyethoxy) phenyl]-2-methyl-1-propanone (I2959) is the most
Pui -Yan Lee et al.
Pharmaceutical research, 37(11), 220-220 (2020-10-15)
Gold porphyrin (AuP) is a complex that has been shown to be potent against various tumors. A biocompatible interpenetrating network (IPN) system comprised of polyethyleneglycol diacrylate (PEGdA) and chemically-modified gelatin has been shown to be an effective implantable drug depot
Juliana S Ribeiro et al.
Biomacromolecules, 21(9), 3945-3956 (2020-08-14)
Oral bacterial infection represents the leading cause of the gradual destruction of tooth and periodontal structures anchoring the teeth. Lately, injectable hydrogels have gained increased attention as a promising minimally invasive platform for localized delivery of personalized therapeutics. Here, an
Joshua D McCall et al.
Biomacromolecules, 13(8), 2410-2417 (2012-06-30)
Photoinitiated polymerization remains a robust method for fabrication of hydrogels, as these reactions allow facile spatial and temporal control of gelation and high compatibility for encapsulation of cells and biologics. The chain-growth reaction of macromolecular monomers, such as acrylated PEG
Afficher tous les articles scientifiques apparentés

Articles

Water-Soluble Photoinitiators

The introduction of LAP and water-dispersible photoinitiator nanoparticles of TPO, enables the development of novel formulations for 3D bioprinting, tissue engineering applications, and device manufacturing.

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Tissue Engineering

Tissue engineering fabricates tissues cultures from scaffolds, living cells, and biologically active molecules by simulating the microenvironment of the body to repair or replace damaged tissue.

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

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