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Key Documents

Autres documents

900671

Sigma-Aldrich

Methoxy poly(ethylene glycol)-block-poly(ε-caprolactone)

5k-2k

Synonyme(s) :

mPEG-b-PCL, mPEG-PCL

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About This Item

Formule linéaire :
CH3O(CH2CH2O)n(COCH2CH2CH2CH2CH2O)mH
Code UNSPSC :
12162002
Nomenclature NACRES :
NA.23

Niveau de qualité

100

Forme

powder

Poids mol.

PCL average Mn ~2,000
PEG average Mn ~5,000

Température de transition

flash point >230 °F
Tm 54-57 °C

Température de stockage

2-8°C

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Application

Biocompatible, amphiphilic block copolymer composed of a hydrophilic PEG block and a hydrophobic PCL block. These materials have been used as a block copolymer surfactant as well as in control release and nanoparticle formulation for drug delivery applications. Well-defined materials with varying properties can be prepared by controlling the relative length of each polymer block. Hydroxyl termination allows for facile further chemical modification of these materials.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

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Simple solvothermalsynthesis of hydrophobic magnetic monodispersed Fe3O4 nanoparticles.
Liu J, et al.
Mat. Res. Bul., 48(2), 416-421 (2013)
On the mechanism of formation of vesicles from poly(ethylene oxide)-block-poly(caprolactone) copolymers.
Adams DJ, et al.
Soft Matter, 5, 3086-3096 (2009)
Xu Wen Ng et al.
Journal of pharmaceutical sciences, 103(11), 3631-3640 (2014-09-17)
Despite the success that drug-eluting stents (DESs) have achieved for minimizing in-stent restenosis (ISR), the antirestenotic agents used in DES have been implicated in delayed endothelial healing and impairment of endothelial functions. Cenderitide (CD-NP) is a novel antiproliferation chimeric peptide
Xu Wen Ng et al.
Drug delivery and translational research, 5(5), 469-479 (2015-06-24)
Timolol maleate (TM) has been used for many years for the reduction of intraocular pressure (IOP) in glaucoma patients. However, the topical mode of administration (eyedrops) is far from optimal because of the issues of low bioavailability, high drug wastage
Bhuvana S Doddapaneni et al.
Journal of controlled release : official journal of the Controlled Release Society, 220(Pt A), 503-514 (2015-11-19)
Metastatic melanoma has a high mortality rate due to lymphatic progression of the disease. Current treatment is surgery followed by radiation and intravenous chemotherapy. However, drawbacks for current chemotherapeutics lie in the fact that they develop resistance and do not
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