900393
Folate-PEG2000-COOH
average Mn 2,000
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About This Item
Formule linéaire :
C19H19N8O5(C2H4O)nC2H3O2
Code UNSPSC :
51171641
Nomenclature NACRES :
NA.23
Produits recommandés
Forme
powder
Niveau de qualité
Poids mol.
average Mn 2,000
Température de transition
Tm 39-49 °C
Température de stockage
−20°C
Application
The folate end group may be used for target-specific cellular uptake of drug delivery vehicles and the carboxylate group can be used for further conjugation to make drug conjugates, polymeric nanoparticles, or folate targeting liposomes.
Informations légales
Product of JenKem Technology.
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
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For folate-receptor-targeted anti-cancer therapy, doxorubicin aggregates in a nano-scale size were produced employing doxorubicin-polyethylene glycol-folate (DOX-PEG-FOL) conjugate. Doxorubicin and folate were respectively conjugated to alpha- and omega-terminal end group of a PEG chain. The conjugates assisted to form doxorubicin nano-aggregates
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Poly(D,L-lactic-co-glycolic acid) (PLGA) nanoparticles with anionic surface charge were surface coated with cationic di-block copolymer, poly(L-lysine)-poly(ethylene glycol)-folate (PLL-PEG-FOL) conjugate, for enhancing their site-specific intracellular delivery against folate receptor overexpressing cancer cells. The PLGA nanoparticles coated with the conjugate were characterized
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