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764698

Sigma-Aldrich

Poly(L-lactide)

average Mn 20,000, PDI ≤1.1

Synonyme(s) :

PLA, PLLA, Polylactide, L-Lactide polymer, PLA, Poly(L-Lactic acid)

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About This Item

Formule linéaire :
H(C3H4O2)nOCH3
Code UNSPSC :
12162002
Nomenclature NACRES :
NA.23

Forme

solid

Niveau de qualité

100

Activité optique

[α]22/D -153°, c = 0.5% in chloroform

Poids mol.

average Mn 20,000

Intervalle de dégradation

>3 years

Température de transition

Tm 167-172 °C

PDI

≤1.1

Température de stockage

2-8°C

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Catégories apparentées

Description générale

Poly (L-lactide) is a semi-crystalline polymer which exhibits strong optical rotation and good mechanical properties. It is mostly used in the synthesis of degradable polymers which are used in orthopaedic devices, in dental applications, as scaffolds for autografted new skin, wound covers, anastomose systems and stents. They are biodegradable since the polyester backbone degrades by simple hydrolysis to form non-toxic compounds.

Application

Used in Drug Delivery including coating nanoparticles. Can be end-group functionalizated or used as a macroinitiator/block precursor.

Caractéristiques et avantages

High initial strength, good strength retention and high amount of crystallinity as much as 70% which in turn is responsible for the very slow degradation rate.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Effect of poly (ethylene glycol)-block- poly (L-lactide) on the poly [(R)-3-hydroxybutyrate]/poly (L-lactide) blends
Yoon, J. S., Lee, W. S., Kim, K. S., Chin, I. J., Kim, M. N., & Kim, C.
Eur. Polymer J., 36(2), 435-442 (2000)
Chemical synthesis of polylactide and its copolymers for medical applications
Bendix, D.
Polymer Degradation and Stability, 59(1), 129-135 (1998)
Synthesis and thermal properties of novel star-shaped poly (l-lactide)s with starburst PAMAM-OH dendrimer macroinitiator.
Zhao, Y. L., Cai, Q., Jiang, J., Shuai, X. T., Bei, J. Z., Chen, C. F., & Xi, F.
Polymer, 43(22), 5819-5825 (2002)
Wolf, Florian F.; et al.
Macromolecules, 42, 5622-5628 (2009)
Zhang, Wen-Bin; et al.
Macromolecules, 44, 2589-2596 (2011)
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Microparticle drug delivery systems have been extensively researched and applied to a wide variety of pharmaceutical and medical applications due to a number of advantages including injectability, local applicability to target tissues and sites, and controlled drug delivery over a given time period.

Poly(Glycerol Sebacate) in Tissue Engineering and Regenerative Medicine

The world of commercial biomaterials has stagnated over the past 30 years as few materials have successfully transitioned from the bench to clinical use. Synthetic aliphatic polyesters have continued to dominate the field of resorbable biomaterials due to their long history and track record of approval with the U.S. Food and Drug Administration (FDA).

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