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Merck

SKP1

S-phase kinase-associated protein 1

Synonymes:
EMC19, OCP-II, OCP2, SKP1A, TCEB1L, p19A
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(6500) Summary: This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Jul 2008]
  • Rat(287280) S-phase kinase-associated protein 1
  • Thale Cress(843928) S-phase kinase-associated protein 1
  • Zebrafish(393716) S-phase kinase-associated protein 1
  • chicken(416319) S-phase kinase-associated protein 1
  • domestic cat(101099017) S-phase kinase-associated protein 1
  • dog(474682) S-phase kinase-associated protein 1
  • cow(615427) S-phase kinase-associated protein 1
  • Goat(100861021) S-phase kinase-associated protein 1
  • sheep(100240716) S-phase kinase-associated protein 1
  • domestic guinea pig(100135616) S-phase kinase-associated protein 1A
  • naked mole-rat(101704606) S-phase kinase-associated protein 1

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Antibodies

Référence du produit
Description
Espèces réactives
Application
Monoclonal Anti-SKP1A, (C-terminal) antibody produced in mouse, clone 2E6, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
ELISA
immunofluorescence

western blot
Anti-SKP1 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
proximity ligation assay
western blot
Monoclonal Anti-SKP1 antibody produced in mouse, clone 4E11, ascites fluid,
Espèces réactives
human
Application
ELISA
flow cytometry

immunofluorescence

immunohistochemistry

western blot
Anti-SKP1A Mouse mAb (1H8), liquid, clone 1H8, Calbiochem®,
Espèces réactives
human
Application
Anti-SKP1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Espèces réactives
human
Application
immunofluorescence

Proteins

Référence du produit
Description
Espèce(s)
SCF-Fbw7 Protein Complex, Active, 10 µg, Active complex of four (4) full length, recombinant human enzymes: Fbw7, Skp1, Cul1 & Rbx1. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.,
Espèce(s)
human
SCF-Skp2 Protein Complex, Active, 10 µg, Active complex of five (5) full length, recombinant human enzymes: Skp1, Skp2, Cul1, Rbx1 & Cks1. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.,
Espèce(s)
human

esiRNA

Référence du produit
Description
Espèce(s)
MISSION® esiRNA, targeting human SKP1,
Espèce(s)
human