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Merck

CYP2D6

cytochrome P450, family 2, subfamily D, polypeptide 6

Synonymes:
CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1
Espèce(s):
Human CYP2D6 (1565), chicken CYP2D6 (417981), domestic cat CYP2D6 (100500743), sheep CYP2D6 (100568286)
ID UniProtKB:
P10635, Q16752, Q2XND6, Q2XND7, Q2XNE0, Q6B012, Q6NXU8
ID du gène:
  • Human(1565) Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • chicken(417981) cytochrome P450, family 2, subfamily D, polypeptide 6
  • domestic cat(100500743) cytochrome 2D6
  • sheep(100568286) cytochrome P450 2D6

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Antibodies

Référence du produit
Description
Espèces réactives
Application
HPA045223
Anti-CYP2D6 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry
western blot
AV41675
Anti-CYP2D6 antibody produced in rabbit, IgG fraction of antiserum,
Espèces réactives
human, rat
Application
immunohistochemistry
western blot
SAB1402166
Monoclonal Anti-CYP2D6 antibody produced in mouse, clone 2C5, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
ELISA
SAB4500595
Anti-Cytochrome P450 2D6 antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human
Application
ELISA
western blot
SAB5702749
Anti-CYP2D6 Antibody, clone 1X3F0, Rabbit Monoclonal, ,
Espèces réactives
human, rat
Application
immunofluorescence
western blot

Small Molecule - Inhibitor

Référence du produit
Description
Espèce(s)
241571
Quinoline, reagent grade, 98%,
Espèce(s)
human
C80407
Cinchonidine, 96%,
Espèce(s)
human
C0253
Chlorambucil, ,
Espèce(s)
human
183067
6-Methoxyquinoline, 98%,
Espèce(s)
human
27370
Cinchonine, crystallized, ≥98.0% (NT),
Espèce(s)
human

Proteins

Référence du produit
Description
Espèce(s)
MTOXCE2D6
CypExpress™ 2D6 Cytochrome P450 human, ,
Espèce(s)
human

esiRNA

Référence du produit
Description
Espèce(s)
EHU115661
MISSION® esiRNA, targeting human CYP2D6,
Espèce(s)
human