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Merck

CACNA1C

calcium channel, voltage-dependent, L type, alpha 1C subunit

Synonymes:
CACH2, CACN2, CACNL1A1, CCHL1A1, CaV1.2, LQT8, TS
Espèce(s):
Human CACNA1C (775), Mouse Cacna1c (12288), Rat Cacna1c (24239), Zebrafish cacna1c (170581), cow CACNA1C (408015), Horse CACNA1C (100049924), chicken CACNA1C (395891), domestic cat CACNA1C (101082923), dog CACNA1C (403516), naked mole-rat Cacna1c (101717129) ...Plus
ID UniProtKB:
Q13936, B2RUT3, E9PDJ0, Q13917, Q13918, Q13919, Q13920, Q13921
ID du gène:
  • Human(775) Summary: This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. [provided by RefSeq, Oct 2012]
  • Mouse(12288) calcium channel, voltage-dependent, L type, alpha 1C subunit
  • Rat(24239) calcium channel, voltage-dependent, L type, alpha 1C subunit
  • Zebrafish(170581) calcium channel, voltage-dependent, L type, alpha 1C subunit
  • cow(408015) calcium channel, voltage-dependent, L type, alpha 1C subunit
  • Horse(100049924) calcium channel, voltage-dependent, L type, alpha 1C subunit
  • chicken(395891) calcium channel, voltage-dependent, L type, alpha 1C subunit
  • domestic cat(101082923) calcium channel, voltage-dependent, L type, alpha 1C subunit
  • dog(403516) calcium channel, voltage-dependent, L type, alpha 1C subunit
  • naked mole-rat(101717129) calcium channel, voltage-dependent, L type, alpha 1C subunit
  • domestic guinea pig(100135490) calcium channel, voltage-dependent, L type, alpha 1C subunit
  • Goat(100861292) calcium channel, voltage-dependent, L type, alpha 1C subunit
  • sheep(101116562) calcium channel, voltage-dependent, L type, alpha 1C subunit

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Small Molecule - Allosteric Modulator

Référence du produit
Description
Espèce(s)
1287303
Gabapentin, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
G-007
Gabapentin solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Espèce(s)
human
G-021
Gabapentin solution, 10 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Espèce(s)
human
PHR1049
Gabapentin, Pharmaceutical Secondary Standard; Certified Reference Material,
Espèce(s)
human
Y0001805
Pregabalin, European Pharmacopoeia (EP) Reference Standard,
Espèce(s)
human

Small Molecule - Antagonist

Référence du produit
Description
Espèce(s)
B112
(±)-Bay K8644, calcium channel agonist,
Espèce(s)
rat
1269389
Felodipine, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
1463858
Nimodipine, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
BP758
Felodipine impurity standard, British Pharmacopoeia (BP) Reference Standard,
Espèce(s)
human
F0030000
Felodipine, European Pharmacopoeia (EP) Reference Standard,
Espèce(s)
human

Antibodies

Référence du produit
Description
Espèces réactives
Application
C1603
Anti-Calcium Channel (α1C Subunit) (L-type of Voltage-gated Ca2+ Channel) antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rabbit, rat
Application
immunohistochemistry
western blot
SAB2500182
Anti-CACNA1C antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Espèces réactives
human
Application
ELISA
western blot
C4980
Anti-Calcium Channel (Cardiac α1C Subunit) (L-type of Voltage-gated Ca2+ Channel) antibody produced in rabbit, affinity isolated antibody, lyophilized powder,
Espèces réactives
rabbit, rat
Application
immunoprecipitation (IP)
western blot
MABN863
Anti-Cav1.2 alpha1c, clone 8F9.1 Antibody, clone 8F9.1, from mouse,
Espèces réactives
human
Application
immunohistochemistry
western blot
AB5156
Anti-Calcium Channel Antibody, Voltage Gated α 1C, Chemicon®, from rabbit,
Espèces réactives
human, mouse, rabbit, rat
Application
immunohistochemistry
immunoprecipitation (IP)
western blot

Small Molecule - Blocker

Référence du produit
Description
Espèce(s)
1711202
Verapamil hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
A5605
Amlodipine besylate, ≥98% (HPLC),
Espèce(s)
human
1029501
Amlodipine besylate, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
N7510
Nicardipine hydrochloride, powder, ≥98%,
Espèce(s)
human
V-002
Verapamil hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®,
Espèce(s)
human

esiRNA

Référence du produit
Description
Espèce(s)
EHU125411
MISSION® esiRNA, targeting human CACNA1C (2),
Espèce(s)
human
EMU084311
MISSION® esiRNA, targeting mouse Cacna1c,
Espèce(s)
mouse
EHU124641
MISSION® esiRNA, targeting human CACNA1C (1),
Espèce(s)
human