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Merck

APP

amyloid beta (A4) precursor protein

Synonymes:
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(351) Summary: This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(11820) amyloid beta (A4) precursor protein
  • Rat(54226) amyloid beta (A4) precursor protein
  • fruit fly(39399) approximated
  • chicken(374198) amyloid beta (A4) precursor protein
  • domestic cat(101085564) amyloid beta (A4) precursor protein
  • cow(280722) amyloid beta (A4) precursor protein
  • dog(403407) amyloid beta (A4) precursor protein
  • naked mole-rat(101724743) amyloid beta (A4) precursor protein
  • domestic guinea pig(100715302) amyloid beta (A4) precursor protein
  • sheep(101111593) amyloid beta (A4) precursor protein

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ELISA

Référence du produit
Description
Espèce(s)
High Sensitivity Human Amyloid β42 ELISA, This High Sensitivity Human Amyloid β42 ELISA is used to measure & quantify Amyloid β42 levels in Neuroscience research.,
Espèce(s)
human
Human APP / Amyloid Beta A4 Protein ELISA Kit, for serum, plasma, cell culture supernatants and urine,
Espèce(s)
human
Human Amyloid β42 Brain ELISA, This Human Amyloid β42 Brain ELISA is used to measure & quantify Amyloid β42 levels in Neuroscience research.,
Espèce(s)
human
High Sensitivity Human Amyloid β40 ELISA, This High Sensitivity Human Amyloid β40 ELISA is used to measure & quantify Amyloid β40 levels in Neuroscience research.,
Espèce(s)
human
Human Amyloid β40 and Amyloid β42 Brain ELISA, ,
Espèce(s)
human

Small Molecule - Antagonist

Référence du produit
Description
Espèce(s)
BTA-1, ≥98% (HPLC), solid,
Espèce(s)
human
Curcumin, from Curcuma longa (Turmeric), powder,
Espèce(s)
human
Curcumin, ≥94% (curcuminoid content), ≥80% (Curcumin),
Espèce(s)
human
Flurbiprofen, cyclooxygenase inhibitor,
Espèce(s)
human, rat

Antibodies

Référence du produit
Description
Espèces réactives
Application
Anticorps anti-APP A4, a. a. 66 à 81 de l′APP {NT}, clone 22C11, clone 22C11, Chemicon®, from mouse,
Espèces réactives
canine, fish, human, monkey, mouse, pig, rat
Application
immunofluorescence
immunohistochemistry

western blot
Anticorps anti-bêta-amyloïde 1-42, Chemicon®, from rabbit,
Espèces réactives
chicken, human, mouse
Application
ELISA
immunohistochemistry

western blot
Anticorps anti-amyloïde β, clone W0-2, clone WO2, from mouse,
Espèces réactives
human, mouse
Application
ELISA
immunohistochemistry

western blot
αβ, serum, Chemicon®,
Espèces réactives
eukaryotes, human, mouse, rat
Application
ELISA
immunofluorescence

immunohistochemistry

immunoprecipitation (IP)

western blot
Anti-Amyloid Antibody, β 1-16, clone DE2, culture supernatant, clone DE2, Chemicon®,
Espèces réactives
bovine, human, monkey
Application
ELISA
immunohistochemistry

western blot

Proteins

Référence du produit
Description
Espèce(s)
Amyloid β Protein Fragment 1-42, ,
Espèce(s)
human
Amyloid β-Protein Fragment 25-35, ≥97% (HPLC),
Espèce(s)
human
Amyloid β Protein Fragment 1-40, ≥90% (HPLC), powder,
Espèce(s)
human
β Amyloid 1-42, aβ, ultra pure, HFIP, recombinant human, ,
Espèce(s)
human
β Amyloid 1-42, aβ, ultra pure, TFA, recombinant human, ,
Espèce(s)
human

esiRNA

Référence du produit
Description
Espèce(s)
MISSION® esiRNA, targeting human APP,
Espèce(s)
human
MISSION® esiRNA, targeting mouse App,
Espèce(s)
mouse