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59680-U

Supelco

Supel™ BioSPME 96-Pin Device

pack of 1 ea

Synonym(s):

Supel™ BioSPME 96-Pin Device

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About This Item

UNSPSC Code:
41104018
NACRES:
NB.21

packaging

pack of 1 ea

Quality Level

100

technique(s)

solid phase microextraction (SPME): suitable

matrix active group

C18 coating

application(s)

clinical
pharmaceutical

compatibility

for use with automated robotic liquid handling systems

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General description

The Supel™ BioSPME 96-Pin Device combines BioSPME technology with high throughput free fraction determination for plasma protein binding studies and other free analyte analyses commonly performed by pharma and clinical laboratories. This fast, micro-sample prep device comprises a 96-pin universal format that fits into the wells of standard 96-well plates. The pins are coated with C18 particles and a patented binder that allows for small analytes of interest to bind, while larger macromolecules cannot. This extraction technique is shown to be more than three times faster than rapid equilibrium dialysis methods with improved data quality. Supel™ BioSPME 96-Pin Device workflow can be performed on automation robots via handling with standard gripper paddles, or alternatively can be achieved using a manual technique.

Analysis Note

small molecules having molecular weights up to 1 kDa and logP range from 1-5

Legal Information

Supel is a trademark of Sigma-Aldrich Co. LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Articles

BioSPME for Plasma Protein Binding Assay: Details of Method Development and Optimization

Determination of plasma protein binding using a SupelTM C18 pin device based BioSPME method for efficient sample preparation, along with a comparison to the equilibrium dialysis method.

Sample Cleanliness Using BioSPME

Learn about Supel™ BioSPME C18 96-pin tool to prepare a clean sample with minimal matrix effects for an LC-MS/MS analysis from human plasma and its comparison with acetonitrile-based precipitation.

Optimizing Serum Sample Preparation for Free Testosterone Determination: A Comparative Analysis Using BioSPME

Optimize serum samples for LC-MS/MS-based free testosterone determination using Supel™ BioSPME 96-pin device and validated equilibrium dialysis methods.

Protein Binding Determination Using Supel™ BioSPME C18 Pin Device as Part of the Manual Methodology With and Without Shaking

The application note describes a comparative analysis of plasma protein binding results for free/bound drugs using two different sample extraction steps, with and without agitation.

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Related Content

Supel™ BioSPME 96-Pin Devices

Supel™ BioSPME 96-Pin devices enhance the speed and simplicity of plasma protein binding studies and analyses of other free analytes, compared to the rapid equilibrium dialysis techniques for accurate and reproducible LCMS results.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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