T4182

Tyrphostin AG 1478

≥98%

• Synonym(s): N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinamine
• Empirical Formula (Hill Notation): C₁₆H₁₄ClN₃O₂
• CAS Number: 175178-82-2
• Molecular Weight: 315.75
• MDL number: MFCD00270914
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278735

Properties

• Quality Level: 100
• Assay: ≥98%
• form: solid
• solubility: 0.1 M HCl: soluble <0.4 mg/mL; DMSO:methanol (1:1): soluble 10 mg/mL, clear, colorless; ethanol: soluble 10 mg/mL; methylene chloride: soluble 10 mg/mL; 0.1 M NaOH: insoluble; 2-hydroxypropyl-β-cyclodextrin: insoluble; H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: COc1cc2ncnc(Nc3cccc(Cl)c3)c2cc1OC
• InChI: 1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)
• InChI key: GFNNBHLJANVSQV-UHFFFAOYSA-N
• Gene Information: human ... EGFR(1956) ; mouse ... Egfr(13649)

Description

Application

Tyrphostin AG 1478 has been used as epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor to study its effect on desmoid cell mobility in boyden chamber motility assays. It has also been used to inhibit phosphorylation of c-Met by exogenous transforming growth factor α in epidermoid carcinoma cell line A431.

Biochem/physiol Actions

Tyrphostin AG 1478 is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. It contributes to the development of hypomagnesemia and cardiac dysfunction in rats. Tyrphostin AG 1478 acts as a potential therapeutic agent for breast cancer.

Selective inhibitor of epidermal growth factor receptor protein

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the EGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

Tyrphostin AG 1478 dissolves in DMSO:MeOH (1:1) at 10 mg/ml to yield a clear, colorless solution. It is also soluble in methylene chloride (10 mg/ml), ethanol (10 mg/ml) and 0.1 N HCl (less than 0.4 mg/ml). However, it is insoluble in water, 2-hydroxypropyl-β-cyclodextrin, and 0.1 N NaOH.

Other Notes

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Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves